Multi-Omics Reveals Impact of Cysteine Feed Concentration and Resulting Redox Imbalance on Cellular Energy Metabolism and Specific Productivity in CHO Cell Bioprocessing.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology journal"
DOI: 10.1002/biot.201900565
Abstract: Chinese hamster ovary (CHO) cells are currently the primary host cell lines used in biotherapeutic manufacturing of monoclonal antibodies (mAbs) and other biopharmaceuticals. Cellular energy metabolism and endoplasmic reticulum (ER) stress are known to greatly… read more here.
Keywords: multi omics; metabolism; productivity; cell ... See more keywords
Multi‐omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer, and product quality
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27899
Abstract: A robust monoclonal antibody (mAb) bioprocess requires physiological parameters such as temperature, pH, or dissolved oxygen to be well‐controlled as even small variations in them could potentially impact the final product quality. For instance, pH… read more here.
Keywords: culture; cell; product quality; multi omics ... See more keywords
Multi-omics data identified TP53 and LRP1B as key regulatory gene related to immune phenotypes via EPCAM in HCC.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer medicine"
DOI: 10.1002/cam4.4594
Abstract: BACKGROUND Many studies showed that the prognosis of hepatocellular carcinoma (HCC) was significantly associated with the expressions of TP53 and LRP1B. However, the potential influence of the two genes on the malignant progression of HCC… read more here.
Keywords: analysis; multi omics; hcc; gene ... See more keywords
Multi-omics analysis of the oncogenic value of copper Metabolism-Related protein COMMD2 in human cancers.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer medicine"
DOI: 10.1002/cam4.5320
Abstract: The copper metabolism MURR1 domain (COMMD) protein family is involved in tumorigenicity of malignant tumors. However, as the member of COMMD, the role of COMMD2 in human tumors remains unknown. read more here.
Keywords: commd2 human; copper metabolism; multi omics;
Multi‐omics approach to elucidate the gut microbiota activity: Metaproteomics and metagenomics connection
Sign Up to like & getrecommendations! Published in 2018 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201700476
Abstract: Over the last few years, the application of high‐throughput meta‐omics methods has provided great progress in improving the knowledge of the gut ecosystem and linking its biodiversity to host health conditions, offering complementary support to… read more here.
Keywords: multi omics; elucidate gut; approach elucidate; omics approach ... See more keywords
Multi-omics characterization of mouse hepatoblastoma identifies novel YAP1 target genes.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32713
Abstract: BACKGROUND & AIMS Hepatoblastoma (HB) is the most common primary liver malignancy in childhood, and lacks targeted therapeutic options. We previously engineered the first Yes Associated Protein 1 (YAP1S127A )-inducible mouse model of HB, demonstrating… read more here.
Keywords: novel yap1; multi omics; mouse; yap1 ... See more keywords
Multi‐omics analysis reveals multiple mechanisms causing Prader–Willi like syndrome in a family with a X;15 translocation
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24440
Abstract: Prader–Willi syndrome (PWS; MIM# 176270) is a neurodevelopmental disorder caused by the loss of expression of paternally imprinted genes within the PWS region located on 15q11.2. It is usually caused by either maternal uniparental disomy… read more here.
Keywords: translocation; multi omics; prader willi; omics analysis ... See more keywords
Identification of seven‐gene marker to predict the survival of patients with lung adenocarcinoma using integrated multi‐omics data analysis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24190
Abstract: The mechanism of cancer occurrence and development could be understood with multi‐omics data analysis. Discovering genetic markers is highly necessary for predicting clinical outcome of lung adenocarcinoma (LUAD). read more here.
Keywords: analysis; multi omics; data analysis; omics data ... See more keywords
Multi‐omics analysis reveals expression complexity and functional diversity of mouse kinome
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DOI: 10.1002/pmic.202200120
Abstract: Protein kinases are a crucial component of signaling pathways involved in a wide range of cellular responses, including growth, proliferation, differentiation, and migration. Systematic investigation of protein kinases is critical to better understand phosphorylation‐mediated signaling… read more here.
Keywords: multi omics; protein kinases; c57bl; analysis ... See more keywords
Integration of Multi-omics Data for Expression Quantitative Trait Loci (eQTL) Analysis and eQTL Epistasis.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0026-9_11
Abstract: Expression quantitative trait loci (eQTL) mapping studies identify genetic loci that regulate gene expression. eQTL mapping studies can capture gene regulatory interactions and provide insight into the genetic mechanism of biological systems. Recently, the integration… read more here.
Keywords: loci; multi omics; omics data; eqtl ... See more keywords
Network-Based Approaches for Multi-omics Integration.
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DOI: 10.1007/978-1-0716-0239-3_23
Abstract: Network-based approach is rapidly emerging as a promising strategy to integrate and interpret different -omics datasets, including metabolomics. The first section of this chapter introduces the current progresses and main concepts in multi-omics integration. The… read more here.
Keywords: network based; network; multi omics; omics integration ... See more keywords