Performance of Liquid Biopsy‐Based Multi‐Omics Biomarkers for Early Detection of Gynecological Malignancies: A Prospective Study (PERCEIVE‐I)
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DOI: 10.1002/advs.202401760
Abstract: Liquid biopsy is a promising approach for early detection of gynecological malignancies. In the PERCEIVE‐I study, gynecological Cancer cases (n = 249) and age‐matched non‐cancer controls (n = 249) are randomly divided into training and… read more here.
Keywords: early detection; gynecological malignancies; multi omics; detection gynecological ... See more keywords
From Multi‐Omics to Visualization and Beyond: Bridging Micro and Macro Insights in CAR‐T Cell Therapy
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DOI: 10.1002/advs.202501095
Abstract: Chimeric antigen receptor T (CAR‐T) cell therapies, a cornerstone of immunotherapy, have demonstrated remarkable efficacy in treating hematological malignancies and have more recently expanded into applications for solid tumors and autoimmune diseases. Emerging multidimensional profiling… read more here.
Keywords: visualization; multi omics; therapy; car cell ... See more keywords
Multi-Omics Reveals Impact of Cysteine Feed Concentration and Resulting Redox Imbalance on Cellular Energy Metabolism and Specific Productivity in CHO Cell Bioprocessing.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology journal"
DOI: 10.1002/biot.201900565
Abstract: Chinese hamster ovary (CHO) cells are currently the primary host cell lines used in biotherapeutic manufacturing of monoclonal antibodies (mAbs) and other biopharmaceuticals. Cellular energy metabolism and endoplasmic reticulum (ER) stress are known to greatly… read more here.
Keywords: multi omics; metabolism; productivity; cell ... See more keywords
Multi‐omics profiling of a CHO cell culture system unravels the effect of culture pH on cell growth, antibody titer, and product quality
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27899
Abstract: A robust monoclonal antibody (mAb) bioprocess requires physiological parameters such as temperature, pH, or dissolved oxygen to be well‐controlled as even small variations in them could potentially impact the final product quality. For instance, pH… read more here.
Keywords: culture; cell; product quality; multi omics ... See more keywords
Decoding Stroke Etiology: Multi‐Omics Advancements in Genetic Mechanisms and Clinical Implication
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DOI: 10.1002/brb3.70792
Abstract: Stroke has a high mortality and disability rate, yet its underlying mechanisms remain not fully understood. The occurrence of stroke is influenced by a combination of environmental factors, genetic factors, and their interaction, making its… read more here.
Keywords: decoding stroke; stroke etiology; multi omics; etiology ... See more keywords
Multi-omics data identified TP53 and LRP1B as key regulatory gene related to immune phenotypes via EPCAM in HCC.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer medicine"
DOI: 10.1002/cam4.4594
Abstract: BACKGROUND Many studies showed that the prognosis of hepatocellular carcinoma (HCC) was significantly associated with the expressions of TP53 and LRP1B. However, the potential influence of the two genes on the malignant progression of HCC… read more here.
Keywords: analysis; multi omics; hcc; gene ... See more keywords
Multi-omics analysis of the oncogenic value of copper Metabolism-Related protein COMMD2 in human cancers.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer medicine"
DOI: 10.1002/cam4.5320
Abstract: The copper metabolism MURR1 domain (COMMD) protein family is involved in tumorigenicity of malignant tumors. However, as the member of COMMD, the role of COMMD2 in human tumors remains unknown. read more here.
Keywords: commd2 human; copper metabolism; multi omics;
Multi‐omics approach to elucidate the gut microbiota activity: Metaproteomics and metagenomics connection
Sign Up to like & getrecommendations! Published in 2018 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201700476
Abstract: Over the last few years, the application of high‐throughput meta‐omics methods has provided great progress in improving the knowledge of the gut ecosystem and linking its biodiversity to host health conditions, offering complementary support to… read more here.
Keywords: multi omics; elucidate gut; approach elucidate; omics approach ... See more keywords
Integrative Multi‐Omics Approach for Improving Causal Gene Identification
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DOI: 10.1002/gepi.22601
Abstract: Transcriptome‐wide association studies (TWAS) have been widely used to identify thousands of likely causal genes for diseases and complex traits using predicted expression models. However, most existing TWAS methods rely on gene expression alone and… read more here.
Keywords: causal gene; multi omics; identification; gene ... See more keywords
Multi-omics characterization of mouse hepatoblastoma identifies novel YAP1 target genes.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32713
Abstract: BACKGROUND & AIMS Hepatoblastoma (HB) is the most common primary liver malignancy in childhood, and lacks targeted therapeutic options. We previously engineered the first Yes Associated Protein 1 (YAP1S127A )-inducible mouse model of HB, demonstrating… read more here.
Keywords: novel yap1; multi omics; mouse; yap1 ... See more keywords
Multi‐omics analysis reveals multiple mechanisms causing Prader–Willi like syndrome in a family with a X;15 translocation
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DOI: 10.1002/humu.24440
Abstract: Prader–Willi syndrome (PWS; MIM# 176270) is a neurodevelopmental disorder caused by the loss of expression of paternally imprinted genes within the PWS region located on 15q11.2. It is usually caused by either maternal uniparental disomy… read more here.
Keywords: translocation; multi omics; prader willi; omics analysis ... See more keywords