Folding Mechanisms: Distinguishing Signatures and Functional Advantages
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.990
Abstract: How is it that cells and organisms have the flexibility to adapt to external perturbation when their constituent biomolecules appear to possess finely-tuned characteristics? While such adaptability is known to emerge in molecular networks, we… read more here.
Keywords: mechanisms distinguishing; distinguishing signatures; folding mechanisms; functional advantages ... See more keywords
Segmentation of the multimodal brain tumor image used the multi-pathway architecture method based on 3D FCN
Sign Up to like & getrecommendations! Published in 2021 at "Neurocomputing"
DOI: 10.1016/j.neucom.2020.10.031
Abstract: Abstract Segmentation of multimodal brain tissues from 3D medical images is of great significance for brain diagnosis. It is required to create an automated and accurate segmentation based on deep-learning network due to the manual… read more here.
Keywords: multimodal brain; segmentation; multi pathway; segmentation multimodal ... See more keywords
A multi pathway coupled domino strategy: I2/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp3, sp2 and sp C–H functionalization
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d1ra07438e
Abstract: I2/TBHP-promoted, one-pot, multi pathway synthesis of imidazopyridines and thiazoles has been achieved through readily available ethylarenes, ethylenearenes and ethynearenes. I2/TBHP as an initiator and oxidant is used to realize the C–H functionalization of this domino… read more here.
Keywords: tbhp promoted; imidazopyridines thiazoles; functionalization; synthesis imidazopyridines ... See more keywords
Involvement of G-triplex and G-hairpin in the multi-pathway folding of human telomeric G-quadruplex
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx766
Abstract: Abstract G-quadruplex (G4) can be formed by G-rich DNA sequences that are widely distributed throughout the human genome. Although G-triplex and G-hairpin have been proposed as G4 folding intermediates, their formation still requires further investigation… read more here.
Keywords: human telomeric; quadruplex; multi pathway; triplex hairpin ... See more keywords
Multi-View Subspace Clustering via Structured Multi-Pathway Network.
Sign Up to like & getrecommendations! Published in 2022 at "IEEE transactions on neural networks and learning systems"
DOI: 10.1109/tnnls.2022.3213374
Abstract: Recently, deep multi-view clustering (MVC) has attracted increasing attention in multi-view learning owing to its promising performance. However, most existing deep multi-view methods use single-pathway neural networks to extract features of each view, which cannot… read more here.
Keywords: pathway network; multi; multi view; multi pathway ... See more keywords
Multi-pathway integrated adjustment mechanism of licorice flavonoids presenting anti-inflammatory activity.
Sign Up to like & getrecommendations! Published in 2019 at "Oncology letters"
DOI: 10.3892/ol.2019.10793
Abstract: Glycyrrhiza, commonly known as licorice, is a herbal medicine that has been used for thousands of years. Licorice contains multiple flavonoids, which possess a variety of biological activities. On the basis of the anti-inflammatory effects… read more here.
Keywords: anti inflammatory; licorice flavonoids; mechanism; pathway integrated ... See more keywords
Hierarchically tumor-activated nanoCRISPR-Cas13a facilitates efficient microRNA disruption for multi-pathway-mediated tumor suppression
Sign Up to like & getrecommendations! Published in 2023 at "Theranostics"
DOI: 10.7150/thno.81776
Abstract: Rationale: CRISPR-Cas13a is an efficient tool for robust RNA knockdown with lower off-target effect, which may be a potentially powerful and safe tool for cancer gene therapy. However, therapeutic effect of current cancer gene therapy… read more here.
Keywords: cas13a; tumor; multi pathway; suppression ... See more keywords