Understanding the Targeting Mechanisms of Multi-Specific Biologics in Immunotherapy with Multiscale Modeling
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101835
Abstract: Summary Immunotherapeutics are frequently associated with adverse side effects due to the elicitation of global immune modulation. To lower the risk of these side effects, recombinant DNA technology is employed to enhance the selectivity of… read more here.
Keywords: understanding targeting; specific biologics; targeting mechanisms; biologics immunotherapy ... See more keywords
Abstract 3477: Maximizing the outcome of CD226 stimulation through targeting beyond TIGIT signaling with combination and multi-specific approaches for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3477
Abstract: The CD226 (DNAM-1) axis has emerged as an important immune-modulatory pathway that regulates T cell and NK cell effector functions in the solid tumor microenvironment. Three inhibitory receptors, TIGIT, CD96, and PVRIG, inhibit the activating… read more here.
Keywords: multi specific; tigit; maximizing outcome; tumor ... See more keywords
General principles of binding between cell surface receptors and multi-specific ligands: A computational study
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DOI: 10.1371/journal.pcbi.1005805
Abstract: The interactions between membrane receptors and extracellular ligands control cell-cell and cell-substrate adhesion, and environmental responsiveness by representing the initial steps of cell signaling pathways. These interactions can be spatial-temporally regulated when different extracellular ligands… read more here.
Keywords: surface receptors; general principles; cell; multi specific ... See more keywords
A Multi-Specific DARPin Potently Neutralizes Shiga Toxin 2 via Simultaneous Modulation of Both Toxin Subunits
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DOI: 10.3390/bioengineering9100511
Abstract: Shiga toxin-producing E. coli (STEC) is a common cause of bloody diarrhea. The pathology of STEC infection derives from two exotoxins—Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2)—that are secreted by STEC in the… read more here.
Keywords: darpin potently; multi specific; specific darpin; toxin ... See more keywords