Selective Conversion of Furoic Acid Derivatives to Multi‐Substituted Furanacrylate by a Ruthenium Catalyst
Sign Up to like & getrecommendations! Published in 2019 at "ChemCatChem"
DOI: 10.1002/cctc.201901365
Abstract: Furanacrylate derivatives, as a class of multi‐substituted furan compounds, have been widely used in drug synthesis, organic functional materials, novel polymer monomers, etc. In this paper, direct alkenylation and decarboxylation‐alkenylation of furoic acid derivatives to… read more here.
Keywords: alkenylation; furoic acid; multi substituted; acid derivatives ... See more keywords
Efficient copper catalysts for CH bond arylation under microwave heating: Direct access to multi-substituted pivanilides
Sign Up to like & getrecommendations! Published in 2017 at "Catalysis Communications"
DOI: 10.1016/j.catcom.2016.11.022
Abstract: Abstract We herein describe a parallel comparison between homogeneous and heterogeneous copper catalysts for microwave-assisted direct C H bond arylation. These catalytic systems feature enhanced catalytic activities, unique bulky ligand/base effects, mild conditions, and operational… read more here.
Keywords: copper catalysts; substituted pivanilides; copper; bond arylation ... See more keywords
Cu-catalyzed regio- and stereoselective sulfonylation of multi-substituted allenes
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DOI: 10.1016/j.tet.2018.12.031
Abstract: Abstract Regio- and stereoselective sulfonylation of allenes under Cu catalysis is described. Allenyl sp carbons exclusively react with TsCN to give the corresponding alkenyl sulfones. The reaction is initiated by addition of tosyl radical to… read more here.
Keywords: multi substituted; catalyzed regio; regio stereoselective; sulfonylation multi ... See more keywords
A catalytic asymmetric one-pot [3+2] cyclization/semipinacol rearrangement sequence: an efficient construction of a multi-substituted 3H-spiro[benzofuran-2,1'-cyclopentane] skeleton.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc00811j
Abstract: A facile and efficient method to form a chiral multi-substituted 3H-spiro[benzofuran-2,1'-cyclopentane] structural unit has been developed via a one-pot [3+2] cyclization/semipinacol rearrangement cascade. A catalysis system of Cu(ii)/BOX has been used to efficiently construct a… read more here.
Keywords: substituted spiro; benzofuran cyclopentane; cyclization; spiro benzofuran ... See more keywords
One-pot synthesis of multi-substituted conjugated dienones by trapping allene carbocations with active ylides.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06405c
Abstract: A Rh(II)/boron reagent co-catalyzed unprecedent transformation was established for the rapid construction of multi-substituted conjugated dienones under mild conditions by trapping allene carbocations with oxonium ylides from simple starting points in yields up to 85%.… read more here.
Keywords: trapping allene; allene carbocations; substituted conjugated; one pot ... See more keywords
Synthesis and Antiproliferatory Activities Evaluation of Multi-Substituted Isatin Derivatives
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DOI: 10.3390/molecules26010176
Abstract: A series of multi-substituted isatin derivatives were synthesized using the powerful Sandmeyer reaction. The structures of these derivatives were confirmed by 1H-NMR, 13C-NMR, and HR-MS. Inhibition of proliferation activities of these derivatives against human leukemia… read more here.
Keywords: activities evaluation; antiproliferatory activities; substituted isatin; multi substituted ... See more keywords
Synthesis, Bioactivity, Pharmacokinetic and Biomimetic Properties of Multi-Substituted Coumarin Derivatives
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DOI: 10.3390/molecules26195999
Abstract: A series of novel multi-substituted coumarin derivatives were synthesized, spectroscopically characterized, and evaluated for their antioxidant activity, soybean lipoxygenase (LOX) inhibitory ability, their influence on cell viability in immortalized human keratinocytes (HaCaT), and cytotoxicity in… read more here.
Keywords: substituted coumarin; methyl chromen; chromen one; synthesis bioactivity ... See more keywords
Atom Economical Multi-Substituted Pyrrole Synthesis from Aziridine
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DOI: 10.3390/molecules27206869
Abstract: Multi-substituted pyrroles are synthesized from regiospecific aziridine ring-opening and subsequent intramolecular cyclization with a carbonyl group at the γ-position in the presence of Lewis acid or protic acid. This method is highly atom economical where… read more here.
Keywords: economical multi; synthesis; atom economical; aziridine ... See more keywords
Multi-Substituted Quinolines as HIV-1 Integrase Allosteric Inhibitors
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DOI: 10.3390/v14071466
Abstract: Allosteric HIV-1 integrase (IN) inhibitors, or ALLINIs, are a new class of antiviral agents that bind at the dimer interface of the IN, away from the enzymatic catalytic site and block viral replication by triggering… read more here.
Keywords: hiv integrase; bromo; substituted quinolines; multi substituted ... See more keywords