A simplified and effective off‐axis Winston–Lutz for single‐isocenter multi‐target SRS
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.13816
Abstract: Abstract Purpose To safely perform single‐iso multi‐target (SIMT) stereotactic radiosurgery (SRS), clinics must demonstrate SRS delivery accuracy for off‐axis targets. The traditional Winston–Lutz (W–L) was widely adopted because it provides a simple and accurate solution… read more here.
Keywords: axis winston; srs; winston lutz; multi target ... See more keywords
Immuno-Engineered Nanodecoys for the Multi-Target Anti-Inflammatory Treatment of Autoimmune Diseases.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced materials"
DOI: 10.1002/adma.202108817
Abstract: Over-activated T cells and over-produced pro-inflammatory cytokines form a self-amplified signaling loop to continuously exacerbate the dysregulated inflammatory response and propel the progression of autoimmune diseases (AIDs). Herein, immuno-engineered nanodecoys (NDs) based on poly(lactic-co-glycolic acid)… read more here.
Keywords: prm; engineered nanodecoys; autoimmune diseases; immuno engineered ... See more keywords
Co‐Assembled Nanoparticles toward Multi‐Target Combinational Therapy of Alzheimer's Disease by Making Full Use of Molecular Recognition and Self‐Assembly
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Materials"
DOI: 10.1002/adma.202401918
Abstract: The complex pathologies in Alzheimer's disease (AD) severely limit the effectiveness of single‐target pharmic interventions, thus necessitating multi‐pronged therapeutic strategies. While flexibility is essentially demanded in constructing such multi‐target systems, for achieving optimal synergies and… read more here.
Keywords: alzheimer disease; multi target; target; combinational therapy ... See more keywords
In Situ Proliferating Peptide Nanoparticle Augments Multi‐Target Intervention of Secondary Brain Damage Following Subarachnoid Hemorrhage
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202417456
Abstract: Subarachnoid hemorrhage (SAH), a lethal stroke subtype, involves complex pathological cascades triggered by neuro‐glial units for persistent neuroinflammation, oxidative damage and programmed neuronal cell death. Single‐target and traditional multi‐target therapies, derived from individual drugs, show… read more here.
Keywords: damage; secondary brain; subarachnoid hemorrhage; multi target ... See more keywords
Antemortem and postmortem rodenticide analysis in forensic toxicology as a part of an LC-MS/MS based multi target screening strategy.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3222
Abstract: Since rodenticides represent a substance group relevant in toxicological analyses, the aim of this work was the development of a complex multi target screening strategy for the identification with liquid chromatography-tandem mass spectrometry. A simple… read more here.
Keywords: strategy; target screening; multi target; screening strategy ... See more keywords
The neuroanatomy of visual extinction following right hemisphere brain damage: Insights from multivariate and Bayesian lesion analyses in acute stroke
Sign Up to like & getrecommendations! Published in 2024 at "Human Brain Mapping"
DOI: 10.1002/hbm.26639
Abstract: Multi‐target attention, that is, the ability to attend and respond to multiple visual targets presented simultaneously on the horizontal meridian across both visual fields, is essential for everyday real‐world behaviour. Given the close link between… read more here.
Keywords: visual extinction; bayesian lesion; multi target; target attention ... See more keywords
Non‐Linear Output Structure Learning: A Novel Multi‐Target Technique for Multi‐Station and Multi‐Index Drought Modelling
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Climatology"
DOI: 10.1002/joc.70105
Abstract: Exiting artificial intelligence‐based drought models estimate a single drought index in a single station. This study advances drought modelling by proposing Non‐linear Output Structure Learning (NOSL) for simultaneously estimating two drought indices at eight stations.… read more here.
Keywords: non linear; output; multi target; index ... See more keywords
Multi‐target Fragments Display Versatile Binding Modes
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Informatics"
DOI: 10.1002/minf.201700042
Abstract: Promiscuity is an interesting concept in fragment‐based drug design as fragments with low specificity can be advantageous for finding many screening hits. We present a PDB‐wide analysis of multi‐target fragments and their binding mode conservation.… read more here.
Keywords: fragments display; target fragments; binding modes; display versatile ... See more keywords
Perspective: Present pesticide discovery paradigms promote the evolution of resistance - learn from nature and prioritize multi-target site inhibitor design.
Sign Up to like & getrecommendations! Published in 2019 at "Pest management science"
DOI: 10.1002/ps.5649
Abstract: For many years, the emphasis of industry discovery programs has been on finding new target sites of pesticides and finding pesticides that inhibit single targets. There had been an emphasis on genomics in finding single… read more here.
Keywords: discovery; multi target; target; target site ... See more keywords
Machine-Learning-Powered, Rapid, Accurate, and Multi-Target Mechanical Metamaterials Inverse Design.
Sign Up to like & getrecommendations! Published in 2025 at "Small"
DOI: 10.1002/smll.202500634
Abstract: Multi-target inverse design, which involves designing multiple targets with different optimization objectives, becomes a key focus in mechanical metamaterials (MMs) design. Specifically, many practical applications impose varying requirements for different sections. For instance, the heel… read more here.
Keywords: mechanical metamaterials; inverse design; multi target; target ... See more keywords
Assessment of the differentiation of Sambucus nigra plant parts using a multi-target and suspect screening by LC-HRMS and ICP-OES
Sign Up to like & getrecommendations! Published in 2025 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-025-06112-7
Abstract: Traditional plant medicine is among the most popular and strongest growing forms of alternative medicine. Based on ancient healing practices, it still plays a significant role in the treatment of many medical conditions. Its impact… read more here.
Keywords: target suspect; plant; suspect screening; multi target ... See more keywords