In Situ Sequencing: A High-Throughput, Multi-Targeted Gene Expression Profiling Technique for Cell Typing in Tissue Sections.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0623-0_20
Abstract: Recent advances of image-based in situ mRNA quantification methods allow to visualize where in a tissue section a set of genes is expressed. It enables to map large numbers of genes in parallel and by… read more here.
Keywords: gene expression; throughput multi; situ sequencing; multi targeted ... See more keywords
A multi-targeted nanoconjugate for light-driven therapy of chronic wounds
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2021.128835
Abstract: Abstract The pathogenic bacteria-induced diabetic ulcer becomes a life-threatening miscellaneous disease and remains a pivotal clinical challenge due to poor healing. To overcome the obstacle, we developed a non-antibiotic strategy based on a three-dimensional multi-targeted… read more here.
Keywords: therapy; targeted nanoconjugate; chronic wounds; charge ... See more keywords
Multi-targeted effects of untapped resources from the Mauritian endemic flora
Sign Up to like & getrecommendations! Published in 2018 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2018.01.020
Abstract: Abstract The Mauritian endemic plants represent untapped resources, which must be probed into to establish therapeutic activities. This study aimed at determining a broad spectrum of in vitro bioactivities of twelve endemic plants. Total phenolics,… read more here.
Keywords: mauritian endemic; multi targeted; untapped resources; resources mauritian ... See more keywords
Multi-targeted 1H/19F MRI unmasks specific danger patterns for emerging cardiovascular disorders
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26146-6
Abstract: Prediction of the transition from stable to acute coronary syndromes driven by vascular inflammation, thrombosis with subsequent microembolization, and vessel occlusion leading to irreversible myocardial damage is still an unsolved problem. Here, we introduce a… read more here.
Keywords: danger; 19f mri; targeted 19f; danger patterns ... See more keywords
Construction of multi-targeted CRISPR libraries in tomato to overcome functional redundancy at genome-scale level
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-59280-6
Abstract: Genetic variance is vital for breeding programs and mutant screening, yet traditional mutagenesis methods wrestle with genetic redundancy and a lack of specificity in gene targeting. CRISPR-Cas9 offers precise, site-specific gene editing, but its application… read more here.
Keywords: redundancy; targeted crispr; multi targeted; gene ... See more keywords
Synthesis of novel vanillin derivatives: novel multi-targeted scaffold ligands against Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2019 at "MedChemComm"
DOI: 10.1039/c9md00048h
Abstract: Alzheimer's disease (AD) is the most common cause of dementia worldwide, normally affecting people aged over 65. Due to the multifactorial nature of this disease, a "multi-target-directed ligands" (MTDLs) approach for the treatment of this… read more here.
Keywords: vanillin derivatives; alzheimer disease; disease; multi targeted ... See more keywords
Development of a multi-targeted chemotherapeutic approach based on G-quadruplex stabilisation and carbonic anhydrase inhibition
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2024.2366236
Abstract: Abstract A novel class of compounds designed to hit two anti-tumour targets, G-quadruplex structures and human carbonic anhydrases (hCAs) IX and XII is proposed. The induction/stabilisation of G-quadruplex structures by small molecules has emerged as… read more here.
Keywords: inhibition; development multi; stabilisation; hcas xii ... See more keywords
Identifying the natural polyphenol catechin as a multi-targeted agent against SARS-CoV-2 for the plausible therapy of COVID-19: an integrated computational approach
Sign Up to like & getrecommendations! Published in 2021 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbaa378
Abstract: Abstract The global pandemic crisis, coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has claimed the lives of millions of people across the world. Development and testing of anti-SARS-CoV-2… read more here.
Keywords: computational approach; targeted agent; covid; sars cov ... See more keywords
Diagnosis of abdominal tuberculosis by multi‐targeted (mpt64 and IS6110) loop‐mediated isothermal amplification assay
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.16036
Abstract: Diagnosis of abdominal TB is an exigent task due to variable anatomical sites and non‐specific clinical manifestations that closely resemble other diseases. Most of the available diagnostic modalities yield low sensitivities and need expertise to… read more here.
Keywords: diagnosis abdominal; isothermal amplification; mediated isothermal; multi targeted ... See more keywords
7959 Combination Therapy Of Multi-Targeted Tyrosine Kinase Inhibitors And Immune Checkpoint Inhibitors In Advanced Adrenocortical Carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the Endocrine Society"
DOI: 10.1210/jendso/bvae163.144
Abstract: Abstract Disclosure: F. Yaylaci Mert: None. V. Balderrama Brondani: None. L.P. Marcal: None. M. Campbell: None. C. Jimenez: None. J. Varghese: None. A. Shah: None. M.A. Habra: None. Background: Adrenocortical carcinoma (ACC) is a rare… read more here.
Keywords: therapy; none; combination; targeted tyrosine ... See more keywords
Histone deacetylase inhibition with givinostat: a multi-targeted mode of action with the potential to halt the pathological cascade of Duchenne muscular dystrophy
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2024.1514898
Abstract: Muscle repair and regeneration are complex processes. In Duchenne muscular dystrophy (DMD), these processes are disrupted by the loss of functional dystrophin, a key part of the transmembrane dystrophin-associated glycoprotein complex that stabilizes myofibers, indirectly… read more here.
Keywords: duchenne muscular; inhibition; targeted mode; multi targeted ... See more keywords