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Published in 2022 at "Molecular diversity"
DOI: 10.1007/s11030-022-10397-6
Abstract: Vernonia amygdalina, a widely consumed West African food herb, can be a boon in the discovery of safe anti-obesity agents given the extensive reports on its anti-obesity and antidiabetic potentials. The main aim of this…
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Keywords:
vernonia amygdalina;
analysis;
identification promising;
obesity ... See more keywords
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Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1009962
Abstract: K-Ras activating mutations are significantly associated with tumor progression and aggressive metastatic behavior in various human cancers including pancreatic cancer. So far, despite a large number of concerted efforts, targeting of mutant-type K-Ras has not…
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Keywords:
molecule inhibitors;
small molecule;
peptide small;
molecule ... See more keywords
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Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0218125
Abstract: Targeted therapies have become the focus of much of the cancer therapy research conducted in the United States. While these therapies have made vast improvements in the treatment of cancer, their results have been somewhat…
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Keywords:
multi targeting;
natural compound;
compound growth;
cancer ... See more keywords
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Published in 2020 at "Orvosi Hetilap"
DOI: 10.1556/650.2020.31703
Abstract: The one disease - one target - one drug paradigm was an almost dominant principle in drug discovery from the 1960s to the 2000s. The stagnation and even decline in the productivity of drug innovation…
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Keywords:
multi targeting;
drug;
pharmacology;
mad spont ... See more keywords
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Published in 2017 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms18081638
Abstract: A key focus in the field of drug discovery has been motivated by the neuroprotection of natural compounds. Cerebral ischemia is a multifaceted pathological process with a series of mechanisms, and a perspective for the…
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Keywords:
multi targeting;
novel inhibitor;
inhibitor potential;
potential therapeutic ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24098148
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disease that causes a gradual loss of normal motor and cognitive function. The complex AD pathophysiology involves various factors such as oxidative stress, neuroinflammation, amyloid-beta (Aβ) aggregation, disturbed neurotransmission,…
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Keywords:
targeting neuroprotective;
neuroprotective effects;
oxidative stress;
extracts key ... See more keywords
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Published in 2020 at "Molecules"
DOI: 10.3390/molecules25092174
Abstract: Essential oils (EOs) are popular in aromatherapy, a branch of alternative medicine that claims their curative effects. Moreover, several studies reported EOs as potential anti-cancer agents by inducing apoptosis in different cancer cell models. In…
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Keywords:
kinase inhibitors;
multi targeting;
inhibitors multi;
essential oils ... See more keywords