Antimicrobial Peptides of Multicellular Organisms: My Perspective.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-3588-4_1
Abstract: Antimicrobial peptides of multicellular organisms were first characterized in the 1980s by investigators who felt that known systems of immunity could not explain what they observed: the resistance to bacterial infection of a Cecropia moth… read more here.
Keywords: biology; organisms perspective; antimicrobial peptides; peptides multicellular ... See more keywords
Single-cell variability in multicellular organisms
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02710-x
Abstract: Noisy gene expression is of fundamental importance to single cells, and is therefore widely studied in single-celled organisms. Extending these studies to multicellular organisms is challenging since their cells are generally not isolated, but individuals… read more here.
Keywords: single cell; cell cell; cell variability; cell ... See more keywords
A computational method using differential gene expression to predict altered metabolism of multicellular organisms.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00462a
Abstract: Altered metabolism is often identified as a cause or an effect of physiology and pathogenesis. But it is difficult to predict the metabolic flux distributions of multicellular organisms due to the lack of an explicit… read more here.
Keywords: altered metabolism; computational method; multicellular organisms; gene expression ... See more keywords
3D manipulation of small multicellular organisms in soft microtubes
Sign Up to like & getrecommendations! Published in 2024 at "AIP Advances"
DOI: 10.1063/5.0231925
Abstract: Small multicellular organisms, such as C. elegans and zebrafish larvae, are essential models in biological research, but their 3D manipulation poses challenges due to their small size. Manual positioning is labor-intensive and imprecise. To address… read more here.
Keywords: soft microtubes; organisms soft; small multicellular; multicellular organisms ... See more keywords
Intercellular competition and the inevitability of multicellular aging
Sign Up to like & getrecommendations! Published in 2017 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1618854114
Abstract: Significance We lay out the first general model of the interplay between intercellular competition, aging, and cancer. Our model shows that aging is a fundamental feature of multicellular life. Current understanding of the evolution of… read more here.
Keywords: inevitability multicellular; selection; competition; intercellular competition ... See more keywords
MACSPI enables tissue-selective proteomic and interactomic analyses in multicellular organisms
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2319060121
Abstract: Significance Multicellular organisms synthesize a specific set of proteins in each cell type to enable cellular differentiation and functions. These proteins interact with each other to form complexes needed for various cellular processes. Despite recent… read more here.
Keywords: cell specific; enables tissue; macspi enables; tissue selective ... See more keywords
High-throughput genetic manipulation of multicellular organisms using a machine-vision guided embryonic microinjection robot
Sign Up to like & getrecommendations! Published in 2024 at "Genetics"
DOI: 10.1093/genetics/iyae025
Abstract: Abstract Microinjection is a technique used for transgenesis, mutagenesis, cell labeling, cryopreservation, and in vitro fertilization in multiple single and multicellular organisms. Microinjection requires specialized skills and involves rate-limiting and labor-intensive preparatory steps. Here, we… read more here.
Keywords: vision guided; machine vision; robot; microinjection ... See more keywords
Extending the Lifespan of Multicellular Organisms via Periodic and Stochastic Intercellular Competition.
Sign Up to like & getrecommendations! Published in 2022 at "Physical review letters"
DOI: 10.1103/physrevlett.128.218101
Abstract: Resolution of the intrinsic conflict between the reproduction of single cells and the homeostasis of a multicellular organism is central to animal biology and has direct impact on aging and cancer. Intercellular competition is indispensable… read more here.
Keywords: extending lifespan; multicellular organisms; lifespan multicellular; intercellular competition ... See more keywords
Electron microscopy reveals evidence for simple multicellularity in the Proterozoic fossil Chuaria
Sign Up to like & getrecommendations! Published in 2017 at "Geology"
DOI: 10.1130/g38680.1
Abstract: Multicellularity arose multiple times in the evolutionary history of eukaryotes, and simple multicellularity may have a deep history tracing back to the Paleoproterozoic. However, complex multicellular organisms with cellular and tissue differentiation did not appear… read more here.
Keywords: fossil; multicellularity; microscopy; electron microscopy ... See more keywords
The Genetics of Autophagy in Multicellular Organisms.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of genetics"
DOI: 10.1146/annurev-genet-022422-095608
Abstract: Autophagy, a lysosome-mediated degradation process evolutionarily conserved from yeast to mammals, is essential for maintaining cellular homeostasis and combating diverse cellular stresses. Autophagy involves de novo synthesis of a double-membrane autophagosome, sequestration of selected cellular… read more here.
Keywords: multicellular organisms; genetics autophagy; autophagy multicellular; degradation ... See more keywords
MicroRNAs: From Mechanism to Organism
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00409
Abstract: MicroRNAs (miRNAs) are short, regulatory RNAs that act as post-transcriptional repressors of gene expression in diverse biological contexts. The emergence of small RNA-mediated gene silencing preceded the onset of multicellularity and was followed by a… read more here.
Keywords: mirna; mechanism; animal; mirna biogenesis ... See more keywords