Surface charge modulates the internalization vs. penetration of gold nanoparticles: comprehensive scrutiny on monolayer cancer cells, multicellular spheroids and solid tumors by SERS modality.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/d0nr00809e
Abstract: Precise control over the dynamics of nanoparticles (NPs) in a tumor microenvironment is highly warranted for the development of an efficient nanotheranostic agent. Even though inductively coupled plasma mass spectrometry can provide a quantitative assessment… read more here.
Keywords: gold nanoparticles; monolayer; penetration; cells multicellular ... See more keywords
Loss of Krüppel‐like factor 9 facilitates stemness in ovarian cancer ascites‐derived multicellular spheroids via Notch1/slug signaling
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DOI: 10.1111/cas.15100
Abstract: The ascites that develops in advanced OC, both at diagnosis and upon recurrence, is a rich source of multicellular spheroids/aggregates (MCSs/MCAs), which are the major seeds of tumor cell dissemination within the abdominal cavity. However,… read more here.
Keywords: like factor; ppel like; ascites derived; cancer ... See more keywords
Unsuccessful mitosis in multicellular tumour spheroids
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DOI: 10.18632/oncotarget.15673
Abstract: Multicellular spheroids are very attractive models in oncology because they mimic the 3D organization of the tumour cells with their microenvironment. We show here using 3 different cell types (mammary TSA/pc, embryonic kidney Hek293 and… read more here.
Keywords: mitosis; unsuccessful mitosis; mitosis multicellular; multicellular tumour ... See more keywords
A systematic multicellular spheroids screening approach lead to the identification of antineoplastic activity in three different plant extracts from the Egyptian flora
Sign Up to like & getrecommendations! Published in 2017 at "journal of applied pharmaceutical science"
DOI: 10.7324/japs.2017.70603
Abstract: Developing natural products as potential antineoplastic drugs is a meticulous process involving both compound isolation and biological testing. Many studies are based on primary screening using tum ... read more here.
Keywords: spheroids screening; screening approach; systematic multicellular; lead identification ... See more keywords