Co‐culturing multicellular tumor models: Modeling the tumor microenvironment and analysis techniques
Sign Up to like & getrecommendations! Published in 2021 at "PROTEOMICS"
DOI: 10.1002/pmic.202000103
Abstract: Advances in two‐dimensional (2D) and three‐dimensional (3D) cell culture over the last 10 years have led to the development of a plethora of methods for cultivating tumor models. More recently, cellular co‐cultures have become a… read more here.
Keywords: tumor models; analysis; culturing multicellular; multicellular tumor ... See more keywords
Multicellular Tumor Spheroids (MCTS) as a 3D In Vitro Evaluation Tool of Nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201702858
Abstract: Multicellular tumor spheroid models (MCTS) are often coined as 3D in vitro models that can mimic the microenvironment of tissues. MCTS have gained increasing interest in the nano-biotechnology field as they can provide easily accessible… read more here.
Keywords: tumor; mcts vitro; tool; multicellular tumor ... See more keywords
The research of chlorine e6 distribution and accumulation in multicellular tumor spheroid model
Sign Up to like & getrecommendations! Published in 2020 at "Optical and Quantum Electronics"
DOI: 10.1007/s11082-020-2218-9
Abstract: Squamous cell carcinoma is the most common type of oral and oropharyngeal cancers. Incomplete surgical removal of the tumor is often the cause of local recurrence of the disease and appearance of metastases. We have… read more here.
Keywords: multicellular tumor; research chlorine; distribution accumulation; chlorine distribution ... See more keywords
Os(II)-Bridged Polyarginine Conjugates: The Additive Effects of Peptides in Promoting or Preventing Permeation in Cells and Multicellular Tumor Spheroids
Sign Up to like & getrecommendations! Published in 2021 at "Inorganic Chemistry"
DOI: 10.1021/acs.inorgchem.1c00769
Abstract: The preparation of two polyarginine conjugates of the complex Os(II) [bis-(4′-(4-carboxyphenyl)-2,2′:6′,2″-terpyridine)] [Os-(Rn)2]x+ (n = 4 and 8; x = 10 and 18) is reported, to explore whether the R8 peptide sequence that promotes cell uptake… read more here.
Keywords: permeation; bridged polyarginine; multicellular tumor; polyarginine conjugates ... See more keywords
Generation of uniform-sized multicellular tumor spheroids using hydrogel microwells for advanced drug screening
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35216-7
Abstract: Even though in vitro co-culture tumor spheroid model plays an important role in screening drug candidates, its wide applications are currently limited due to the lack of reliable and high throughput methods for generating well-defined… read more here.
Keywords: uniform sized; multicellular tumor; tumor spheroids; sized multicellular ... See more keywords
Modular peptide-functionalized gold nanorods for effective glioblastoma multicellular tumor spheroid targeting.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials science"
DOI: 10.1039/c7bm01107e
Abstract: Glioblastoma multiforme (GBM) contains a population of tumor initiating stem-like cells, termed cancer stem cells (CSCs). These CSCs, which are resistant to chemo- and radiotherapy, are thought to persist after treatment and drive tumor recurrence.… read more here.
Keywords: glioblastoma; modular peptide; gbm; multicellular tumor ... See more keywords
Induction of hypoxia and necrosis in multicellular tumor spheroids is associated with resistance to chemotherapy treatment
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.13857
Abstract: Culture of cancerous cells in standard monolayer conditions poorly mirrors growth in three-dimensional architectures typically observed in a wide majority of cancers of different histological origin. Multicellular tumor spheroid (MCTS) culture models were developed to… read more here.
Keywords: tumor; treatment; multicellular tumor; resistance ... See more keywords
Generation of multicellular tumor spheroids with micro-well array for anticancer drug combination screening based on a valuable biomarker of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1087656
Abstract: Hepatocellular carcinoma (HCC) is a highly malignant tumor with a poor prognosis. More than 30% of patients with diagnosed HCC have abnormally high expression of fibroblast growth factor receptor 4 (FGFR4). Currently, clinical trials for… read more here.
Keywords: hepatocellular carcinoma; drug combination; multicellular tumor; tumor spheroids ... See more keywords
MicroRNAs Regulate Metabolic Phenotypes During Multicellular Tumor Spheroids Progression
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.582396
Abstract: During tumor progression, cancer cells rewire their metabolism to face their bioenergetic demands. In recent years, microRNAs (miRNAs) have emerged as regulatory elements that inhibit the translation and stability of crucial mRNAs, some of them… read more here.
Keywords: metabolism; multicellular tumor; cancer; progression ... See more keywords
Loss of PTEN in Fallopian Tube Epithelium Results in Multicellular Tumor Spheroid Formation and Metastasis to the Ovary
Sign Up to like & getrecommendations! Published in 2019 at "Cancers"
DOI: 10.3390/cancers11060884
Abstract: High-grade serous ovarian cancer (HGSOC) can originate in the fallopian tube and then spread to the ovary. Our objective was to evaluate the role of multicellular tumor spheroids (MTS) in ovarian metastasis. By testing a… read more here.
Keywords: fallopian tube; multicellular tumor; formation; loss pten ... See more keywords
A Novel 3D Culture Scaffold to Shorten Development Time for Multicellular Tumor Spheroids
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232213962
Abstract: Multicellular tumor spheroids and tumoroids are considered ideal in vitro models that reflect the features of the tumor microenvironment. Biomimetic components resembling the extracellular matrix form scaffolds to provide structure to 3-dimensional (3D) culture systems,… read more here.
Keywords: culture; cell; acd culture; multicellular tumor ... See more keywords