Co‐culturing multicellular tumor models: Modeling the tumor microenvironment and analysis techniques
Sign Up to like & getrecommendations! Published in 2021 at "PROTEOMICS"
DOI: 10.1002/pmic.202000103
Abstract: Advances in two‐dimensional (2D) and three‐dimensional (3D) cell culture over the last 10 years have led to the development of a plethora of methods for cultivating tumor models. More recently, cellular co‐cultures have become a… read more here.
Keywords: tumor models; analysis; culturing multicellular; multicellular tumor ... See more keywords
Multicellular Tumor Spheroids (MCTS) as a 3D In Vitro Evaluation Tool of Nanoparticles.
Sign Up to like & getrecommendations! Published in 2018 at "Small"
DOI: 10.1002/smll.201702858
Abstract: Multicellular tumor spheroid models (MCTS) are often coined as 3D in vitro models that can mimic the microenvironment of tissues. MCTS have gained increasing interest in the nano-biotechnology field as they can provide easily accessible… read more here.
Keywords: tumor; mcts vitro; tool; multicellular tumor ... See more keywords
The research of chlorine e6 distribution and accumulation in multicellular tumor spheroid model
Sign Up to like & getrecommendations! Published in 2020 at "Optical and Quantum Electronics"
DOI: 10.1007/s11082-020-2218-9
Abstract: Squamous cell carcinoma is the most common type of oral and oropharyngeal cancers. Incomplete surgical removal of the tumor is often the cause of local recurrence of the disease and appearance of metastases. We have… read more here.
Keywords: multicellular tumor; research chlorine; distribution accumulation; chlorine distribution ... See more keywords
Os(II)-Bridged Polyarginine Conjugates: The Additive Effects of Peptides in Promoting or Preventing Permeation in Cells and Multicellular Tumor Spheroids
Sign Up to like & getrecommendations! Published in 2021 at "Inorganic Chemistry"
DOI: 10.1021/acs.inorgchem.1c00769
Abstract: The preparation of two polyarginine conjugates of the complex Os(II) [bis-(4′-(4-carboxyphenyl)-2,2′:6′,2″-terpyridine)] [Os-(Rn)2]x+ (n = 4 and 8; x = 10 and 18) is reported, to explore whether the R8 peptide sequence that promotes cell uptake… read more here.
Keywords: permeation; bridged polyarginine; multicellular tumor; polyarginine conjugates ... See more keywords
Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG
Sign Up to like & getrecommendations! Published in 2025 at "Oncogene"
DOI: 10.1038/s41388-025-03533-7
Abstract: It has become evident from decades of clinical trials that multimodal therapeutic approaches with focus on cell intrinsic and microenvironmental cues are needed to improve understanding and treat the rare, inoperable, and ultimately fatal diffuse… read more here.
Keywords: tumor stromal; tumor; cell; model ... See more keywords
Generation of uniform-sized multicellular tumor spheroids using hydrogel microwells for advanced drug screening
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35216-7
Abstract: Even though in vitro co-culture tumor spheroid model plays an important role in screening drug candidates, its wide applications are currently limited due to the lack of reliable and high throughput methods for generating well-defined… read more here.
Keywords: uniform sized; multicellular tumor; tumor spheroids; sized multicellular ... See more keywords
Modular peptide-functionalized gold nanorods for effective glioblastoma multicellular tumor spheroid targeting.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials science"
DOI: 10.1039/c7bm01107e
Abstract: Glioblastoma multiforme (GBM) contains a population of tumor initiating stem-like cells, termed cancer stem cells (CSCs). These CSCs, which are resistant to chemo- and radiotherapy, are thought to persist after treatment and drive tumor recurrence.… read more here.
Keywords: glioblastoma; modular peptide; gbm; multicellular tumor ... See more keywords
Optical coherence tomography for multicellular tumor spheroid category recognition and drug screening classification via multi-spatial-superficial-parameter and machine learning
Sign Up to like & getrecommendations! Published in 2024 at "Biomedical Optics Express"
DOI: 10.1364/boe.514079
Abstract: Optical coherence tomography (OCT) is an ideal imaging technique for noninvasive and longitudinal monitoring of multicellular tumor spheroids (MCTS). However, the internal structure features within MCTS from OCT images are still not fully utilized. In… read more here.
Keywords: optical coherence; machine learning; tumor; multicellular tumor ... See more keywords
Induction of hypoxia and necrosis in multicellular tumor spheroids is associated with resistance to chemotherapy treatment
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.13857
Abstract: Culture of cancerous cells in standard monolayer conditions poorly mirrors growth in three-dimensional architectures typically observed in a wide majority of cancers of different histological origin. Multicellular tumor spheroid (MCTS) culture models were developed to… read more here.
Keywords: tumor; treatment; multicellular tumor; resistance ... See more keywords
Generation of multicellular tumor spheroids with micro-well array for anticancer drug combination screening based on a valuable biomarker of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.1087656
Abstract: Hepatocellular carcinoma (HCC) is a highly malignant tumor with a poor prognosis. More than 30% of patients with diagnosed HCC have abnormally high expression of fibroblast growth factor receptor 4 (FGFR4). Currently, clinical trials for… read more here.
Keywords: hepatocellular carcinoma; drug combination; multicellular tumor; tumor spheroids ... See more keywords
MicroRNAs Regulate Metabolic Phenotypes During Multicellular Tumor Spheroids Progression
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.582396
Abstract: During tumor progression, cancer cells rewire their metabolism to face their bioenergetic demands. In recent years, microRNAs (miRNAs) have emerged as regulatory elements that inhibit the translation and stability of crucial mRNAs, some of them… read more here.
Keywords: metabolism; multicellular tumor; cancer; progression ... See more keywords