OER‐073: A multicenter phase 2 study evaluating the role of pazopanib in angiosarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer"
DOI: 10.1002/cncr.34403
Abstract: Angiosarcomas are rare mesenchymal sarcomas that can present as primary cutaneous or noncutaneous disease. They express a variety of vascular endothelial growth factor receptors. The authors hypothesized that the treatment of angiosarcoma with pazopanib, a… read more here.
Keywords: oer 073; pazopanib; 073 multicenter; multicenter phase ... See more keywords
A multicenter phase II prospective clinical trial of glucocorticoid for patients with untreated IgG4-related disease
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DOI: 10.1080/14397595.2016.1259602
Abstract: Abstract Objective: Although glucocorticoids are effective for patients with IgG4-related disease, the treatment has not yet been standardized. Therefore, the treatment strategy should be established. Patients and methods: Patients who fulfilled the comprehensive diagnostic criteria… read more here.
Keywords: related disease; definite igg4; treatment; multicenter phase ... See more keywords
Anlotinib plus chemotherapy for T790M‐negative EGFR ‐mutant non‐sqNSCLC resistant to TKIs: A multicenter phase 1b/2 trial
Sign Up to like & getrecommendations! Published in 2022 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.14713
Abstract: This multicenter phase 1b/2 trial aimed to explore the maximum tolerated dose (MTD), activity, and safety of anlotinib plus chemotherapy in patients with T790M‐negative epidermal growth factor receptor (EGFR)‐mutant advanced nonsquamous non‐small cell lung cancer… read more here.
Keywords: t790m negative; plus chemotherapy; anlotinib plus; egfr mutant ... See more keywords
Multicenter, phase III trials on the contraceptive efficacy, tolerability and safety of a new drospirenone‐only pill
Sign Up to like & getrecommendations! Published in 2019 at "Acta Obstetricia et Gynecologica Scandinavica"
DOI: 10.1111/aogs.13688
Abstract: Approximately 100 million women currently use combined oral contraceptives. Combined oral contraceptives use is associated with increased risk of venous thromboembolic events and cardiovascular disease. Progestin‐only pills do not increase the risk of venous thromboembolic… read more here.
Keywords: thromboembolic events; tolerability; drospirenone; pill ... See more keywords
Multicenter phase II trial (SWOG S1609, cohort 51) of ipilimumab and nivolumab in metastatic or unresectable angiosarcoma: a substudy of dual anti-CTLA-4 and anti-PD-1 blockade in rare tumors (DART)
Sign Up to like & getrecommendations! Published in 2021 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-002990
Abstract: Purpose Angiosarcoma is a rare aggressive endothelial cell cancer with high mortality. Isolated reports suggest immune checkpoint inhibition efficacy in angiosarcoma, but no prospective studies have been published. We report results for angiosarcoma treated with… read more here.
Keywords: trial; anti; multicenter phase; ipilimumab nivolumab ... See more keywords
Results of Multicenter Phase II Study With Imatinib Mesylate in Allogeneic Recipients With Steroid-Refractory Chronic GVHD
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DOI: 10.1177/09636897221113789
Abstract: In this multicenter phase II study, we evaluated the safety and efficacy of imatinib in patients with steroid-resistant chronic graft-versus-host disease (cGVHD) and evaluated the quality of life (QOL) of the enrolled patients using the… read more here.
Keywords: steroid refractory; multicenter phase; phase study; cgvhd ... See more keywords
A randomized, multicenter phase 3 study of durvalumab (D) and tremelimumab (T) as first-line treatment in patients with unresectable hepatocellular carcinoma (HCC): HIMALAYA study.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.tps4144
Abstract: TPS4144Background: Thus far, sorafenib remains the standard of care for first line systemic therapy in patients with advanced HCC but patient prognosis and quality of life (QOL) continues to be poo... read more here.
Keywords: first line; study; multicenter phase; randomized multicenter ... See more keywords
Multicenter phase I/II trial of BBI608 and pembrolizumab combination in patients with metastatic colorectal cancer (SCOOP Study): EPOC1503.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.760
Abstract: 760Background: The anti–programmed death 1 (PD-1) antibody, pembrolizumab provided an objective response rate (ORR) of 40% in patients (pts) with Mismatch Repair–Deficient (dMMR) or Microsatellite ... read more here.
Keywords: bbi608 pembrolizumab; trial bbi608; combination patients; multicenter phase ... See more keywords
A single-arm multicenter phase II trial of doxorubicin (Doxo) in combination with trabectedin (Trab) given as first-line treatment to patients with metastatic/advanced uterine (U-LMS) and soft tissue leiomyosarcoma (ST-LMS): Final results of the LMS-02 study.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.11506
Abstract: 11506Background: U-LMS and ST-LMS are rare tumors with poor prognosis when locally advanced or metastatic, and with moderate chemosensitivity. Overall response rates (ORR) given in the 1st-line set... read more here.
Keywords: line; trial doxorubicin; multicenter phase; single arm ... See more keywords
A multicenter phase II trial of tumor treating fields plus chemotherapy for first-line treatment of gastric adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.4_suppl.tps474
Abstract: TPS474Background: Gastric carcinoma (GC) is the third-leading cause of death in China (291,000 deaths in 2015). Current therapies include surgery, chemotherapy, radiotherapy and targeted therapy, w... read more here.
Keywords: chemotherapy; phase trial; multicenter phase; treating fields ... See more keywords
A Multicenter Phase 2 Study on the Feasibility and Efficacy of Neoadjuvant Chemotherapy Without Radiotherapy for Locally Advanced Rectal Cancer
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DOI: 10.1245/s10434-017-5967-3
Abstract: BackgroundThis prospective multicenter phase 2 study aimed to evaluate the feasibility and efficacy of neoadjuvant chemotherapy (NAC) without radiotherapy for locally advanced rectal cancer (LARC).MethodsPatients with LARC (cStage II and III) were included in the… read more here.
Keywords: study; efficacy neoadjuvant; multicenter phase; rate ... See more keywords