Nickel-Catalyzed Multicomponent Coupling: Synthesis of α-Chiral Ketones by Reductive Hydrocarbonylation of Alkenes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c07851
Abstract: A nickel-catalyzed, multicomponent regio- and enantioselective coupling via sequential hydroformylation and carbonylation from readily available starting materials has been developed. This modular multicomponent hydrofunctionalization strategy enables the straightforward reductive hydrocarbonylation of a broad range of… read more here.
Keywords: coupling synthesis; multicomponent coupling; nickel catalyzed; catalyzed multicomponent ... See more keywords
Stereoselective Synthesis of Polyketide Motifs via Nickel-Catalyzed Multicomponent Coupling of Aldehydes, Dienes, and Boronic Acids: Reaction Development and Mechanistic Insights.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.5c17153
Abstract: Polyketides are renowned for their structural complexity and potent biological activity, yet efficient and stereocontrolled synthesis of their densely functionalized motifs remains a formidable challenge. Here, we report a nickel-catalyzed, stereoselective multicomponent coupling that assembles… read more here.
Keywords: multicomponent coupling; synthesis; polyketide motifs; stereoselective synthesis ... See more keywords