Systematic comparison of racemic and enantiopure multicomponent crystals of phenylsuccinic acid—the role of chirality
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DOI: 10.1039/d0ce00072h
Abstract: The effect of chirality was investigated by designing, synthesizing and analysing a series of racemic multicomponent crystals and their homochiral counterparts. Eleven new crystalline materials were synthesised by combining phenylsuccinic acid (racemate or the S-enantiomer)… read more here.
Keywords: systematic comparison; multicomponent crystals; chirality; phenylsuccinic acid ... See more keywords
Multicomponent crystals of anti-tuberculosis drugs: a mini-review
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DOI: 10.1039/d0ra06478e
Abstract: Tuberculosis (TB) is the leading cause of death from a single infectious agent globally. Some of the early research on TB treatment indicated drug resistance as one of the key challenges in fighting this disease.… read more here.
Keywords: multicomponent crystals; active pharmaceutical; drug; tuberculosis ... See more keywords
Multicomponent crystals of an artemisinin derivative and cinchona alkaloids for use as antimalarial drugs
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DOI: 10.1039/d1ce00974e
Abstract: Multicomponent crystals of an artemisinin derivative and cinchona alkaloids were produced, combining two major types of antimalaria drugs with unique hydrogen bond interactions. These salts demonstrate a new category of antimalarial pharmaceuticals. read more here.
Keywords: multicomponent crystals; cinchona alkaloids; derivative cinchona; artemisinin derivative ... See more keywords
Charting the salt–cocrystal continuum of acid–base multicomponent crystals with hybrid density functional theory
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DOI: 10.1039/d4ce00903g
Abstract: The protonation state in acid–base multicomponent crystals is challenging to determine. An efficient procedure, leveraging modern implementations of hybrid density functional theory (DFT), is shown to efficiently identify the nature of such crystals. read more here.
Keywords: multicomponent crystals; hybrid density; base multicomponent; functional theory ... See more keywords
Rietveld refinement and NMR crystallographic investigations of multicomponent crystals containing alkali metal chlorides and urea
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DOI: 10.1107/s1600576725001360
Abstract: New mechanochemical preparations of three multicomponent crystals (MCCs) of the form MCl:urea·xH2O (M = Li, Na and Cs) are reported. Their structures were determined by an NMR crystallography approach, combining Rietveld refinement of synchrotron powder… read more here.
Keywords: multicomponent crystals; refinement nmr; alkali metal; rietveld refinement ... See more keywords