Isocyanide-Based Multicomponent Reaction to Approach N-H Functionalization of Indole Using N-Acyliminium Ion as Key Intermediate
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201700826
Abstract: The present work discloses an efficient multicomponent reaction of isocyanide, allenoate, and indole. In the absence of any catalyst, this protocol provides a rapid and direct access to furnish N-H functionalization of indole from readily… read more here.
Keywords: isocyanide based; functionalization indole; multicomponent reaction;
Investigation of the multicomponent reaction of 5-hydroxy-2-methyl-4H-pyran-4-one with carbonyl compounds and Meldrum's acid
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-019-02542-1
Abstract: Herein, we report the studies of the multicomponent reaction of 5-hydroxy-2-methyl-4H-pyran-4-one with carbonyl compounds and Meldrum's acid. General methods for the synthesis of 6-methyl-3,4-dihydropyrano[3,2-b]pyran-2,8-diones, 3-(3-hydroxy-6-methyl-4-oxo-4H-pyran-2-yl)propanoic acid amides and esters, as well as 7-oxo-7H-furo[3,2-b]pyran-3-ylacetic acids were… read more here.
Keywords: methyl; multicomponent reaction; hydroxy methyl; reaction hydroxy ... See more keywords
Multicomponent reaction for the synthesis of highly functionalized piperidine scaffolds catalyzed by TMSI
Sign Up to like & getrecommendations! Published in 2020 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-020-04208-6
Abstract: An efficient method for the synthesis of highly functionalized piperidines via one-pot domino reaction of β-ketoesters, aromatic aldehydes, and aromatic amines was reported. This multicomponent coupling was catalyzed by TMSI in methanol at room temperature,… read more here.
Keywords: synthesis highly; highly functionalized; multicomponent reaction; catalyzed tmsi ... See more keywords
Facile fabrication of organic dyed polymer nanoparticles with aggregation-induced emission using an ultrasound-assisted multicomponent reaction and their biological imaging.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2018.01.084
Abstract: Ultrasound as a powerful technique has increasingly been used in both industry and academia in recent years. Herein, an efficient approach to the ultrafast preparation of cross-linked fluorescent copolymers (PEGMA-AEMA-TPE) with aggregation-induced emission (AIE) via… read more here.
Keywords: aggregation; multicomponent reaction; aggregation induced; assisted multicomponent ... See more keywords
Divergent synthesis of functionalized thioethers via multicomponent reaction of benzynes
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.04.072
Abstract: Abstract Diverse functionalized thioethers were efficiently synthesized through the multicomponent reaction of benzynes, cyclic thioethers and different nucleophiles. Both inorganic salts (KF, KCl, KBr, and KSCN) and silylated reagents (TMSCN, TMSN3, TMSCl) can be utilized… read more here.
Keywords: divergent synthesis; multicomponent reaction; functionalized thioethers; synthesis functionalized ... See more keywords
New method for the synthesis of chromeno[4,3-b]chromene derivatives via multicomponent reaction promoted by niobium pentachloride
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.01.062
Abstract: Abstract Chromeno[4,3-b]chromene derivatives were synthesized from multicomponent reaction between 4-hydroxycoumarin, aryl aldehyde derivatives and 1,3-cyclohexanedione promoted by niobium pentachloride. This new method is simple, cost-effective, provides good yields with good substrate generality and can be… read more here.
Keywords: multicomponent reaction; promoted niobium; chromene derivatives; reaction ... See more keywords
Synthesis of functionalized iodoalkenes using a multicomponent reaction triggered by electrophilic iodination of alkenyldiazoacetates
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2018.03.063
Abstract: Abstract Diazo compounds are frequently used as precursors of metal carbenoids and act as soft nucleophiles even without the use of metal catalysts. The resulting diazonium species may also be trapped by various nucleophiles. The… read more here.
Keywords: functionalized iodoalkenes; multicomponent reaction; synthesis functionalized; reaction ... See more keywords
Ligand-Controlled Palladium-Catalyzed Chemoselective Multicomponent Reaction of Olefin-Tethered Aryl Halides, Isocyanides, and Carboxylic Acids: Diversified Synthesis of Imides.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02297
Abstract: The first palladium-catalyzed, ligand-controlled chemoselective synthesis of imides has been achieved. An orthogonal set of conditions has been developed for multicomponent reaction of various olefin-tethered aryl iodides, isocyanides, and carboxylic acids. Alkylimides ("cyclization on" products)… read more here.
Keywords: olefin tethered; multicomponent reaction; synthesis imides; palladium catalyzed ... See more keywords
Enantioselective Isocyanide-based Multicomponent Reaction with Alkylidene Malonates and Phenols.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c01792
Abstract: A highly enantioselective isocyanide-based multicomponent reaction catalyzed by a chiral N,N'-dioxide/MgII complex was reported. A wide range of substrates were tolerated in this reaction, including alkyl- and aryl-substituted isocyanides with alkylidene malonates and various phenols,… read more here.
Keywords: multicomponent reaction; alkylidene malonates; enantioselective isocyanide; reaction ... See more keywords
Multicomponent Reaction of Isocyanide, Ditelluride, and Mn(III) Carboxylate: Synthesis of N-Acyl Tellurocarbamate.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00824
Abstract: A multicomponent reaction of isocyanides, ditellurides and manganese(III) carboxylates under mild reaction conditions leads to the synthesis of various N-acyl tellurocarbamates. This method demonstrates good functional tolerance and broad substrate scope and, as a result,… read more here.
Keywords: iii; synthesis; acyl; reaction ... See more keywords
Regioselective Synthesis of Fully Substituted Fused Pyrroles through an Oxidant-Free Multicomponent Reaction.
Sign Up to like & getrecommendations! Published in 2023 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03889
Abstract: The synthesis of fully substituted fused pyrroles through a multicomponent reaction between a thioamide, an aldehyde, and ammonium acetate is described. This process improves on a route commonly employed in the patent literature by avoiding… read more here.
Keywords: fused pyrroles; multicomponent reaction; substituted fused; reaction ... See more keywords