A Focused Library of NO‐Donor Compounds with Potent Antiproliferative Activity Based on Green Multicomponent Reactions
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201900385
Abstract: Cancer is the second leading cause of death worldwide. Herein, a strategy to quickly and efficiently identify novel lead compounds to develop anticancer agents, using green multicomponent reactions followed by antiproliferative activity and structure–activity relationship… read more here.
Keywords: multicomponent reactions; green multicomponent; focused library; potent antiproliferative ... See more keywords
Local Anesthetics via Multicomponent Reactions
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200246
Abstract: Local anesthetics occupy a prime position in clinical medicine as they temporarily relieve the pain by blocking voltage‐gated sodium channels. However, limited structural diversity, problems with the efficiency of syntheses and increasing toxicity, mean that… read more here.
Keywords: multicomponent reactions; methodology; local anesthetics; via multicomponent ... See more keywords
SYNTHESIS OF FUNCTIONALIZED OXAZOLIDINES BY MULTICOMPONENT REACTIONS OF 1,2-AMINO ALCOHOLS
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/5439
Abstract: Recent (2011–2019) multicomponent syntheses of functionalized oxazolidines using 1,2-amino alcohols as starting materials are reviewed. The synthetic strategies are gathered into three groups: metal-free domino annulation/Mannich reactions, transition metal-catalyzed cascade reactions, extended one-pot asymmetric azaelectrocyclization. read more here.
Keywords: multicomponent reactions; functionalized oxazolidines; synthesis functionalized; reactions amino ... See more keywords
Tetrahydro-4H-thiopyran-4-one in multicomponent reactions (microreview)
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-019-02399-4
Abstract: This paper summarizes multicomponent reactions with the participation of tetrahydro-4H-thiopyran-4-one, mainly resulting in the formation of sulfur- and nitrogen-containing polyheterocyclic systems, that have been published over the last 7 years. read more here.
Keywords: multicomponent reactions; thiopyran one; reactions microreview; one multicomponent ... See more keywords
New application of decaniobate salt as basic solid in the synthesis of 4H-pyrans by microwave assisted multicomponent reactions
Sign Up to like & getrecommendations! Published in 2018 at "Research on Chemical Intermediates"
DOI: 10.1007/s11164-018-3440-y
Abstract: This study focuses on the search of new applications of polyoxometalates known as decaniobate ions [Nb10O28]6−. The decaniobates can be used as basic solid catalysts in multicomponent reactions to obtain good yields to 4H-pyrans (> 95%)… read more here.
Keywords: multicomponent reactions; decaniobate; new application; pyrans microwave ... See more keywords
The combination of controlled living polymerization and multicomponent reactions to prepare tetraphenylethylene-containing fluorescent block copolymers
Sign Up to like & getrecommendations! Published in 2019 at "Dyes and Pigments"
DOI: 10.1016/j.dyepig.2019.107673
Abstract: Abstract High-efficiency multicomponent reactions (MCRs) have received increasing attention and widely used to prepare functional materials because of many prominent advantages such as simple “one-pot” operation, clear product structure, atom economic and environmentally friendly. Combining… read more here.
Keywords: combination; block copolymers; multicomponent reactions; polymerization ... See more keywords
Data storage in sequence-defined macromolecules via multicomponent reactions
Sign Up to like & getrecommendations! Published in 2018 at "European Polymer Journal"
DOI: 10.1016/j.eurpolymj.2018.04.038
Abstract: Abstract Sequence-defined and information coding macromolecules suitable for data storage materials were synthesized via a combination of two multicomponent reactions. Thus, a well-established protocol based on the Passerini reaction was combined for the first time… read more here.
Keywords: sequence defined; multicomponent reactions; data storage; information ... See more keywords
Aqueous phase environmental friendly organic corrosion inhibitors derived from one step multicomponent reactions: A review
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2018.11.040
Abstract: Abstract Use of organic compounds as corrosion inhibitors is one of the most profitable, effective and ease methods because of their simplicity and cost-effective synthesis using commercially available inexpensive starting materials. Nowadays, the synthesis of… read more here.
Keywords: inhibitors derived; environmental friendly; aqueous phase; corrosion ... See more keywords
Towards click chemistry: Multicomponent reactions via combinations of name reactions
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.04.076
Abstract: Abstract In this report, we try to show the importance of incorporation of name reactions in the sequential cascade reaction in which significantly decreasing the number of steps towards an ideal and practical multi-step synthesis… read more here.
Keywords: multicomponent reactions; click chemistry; chemistry; chemistry multicomponent ... See more keywords
Diverse synthesis of pyrimido[1,2-a]benzimidazoles and imidazo[2,1-b]benzothiazoles via CuI-catalyzed decarboxylic multicomponent reactions of heterocyclic azoles, aldehydes and alkynecarboxylic acids
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2019.01.009
Abstract: Abstract We have developed a straightforward approach to diverse synthesis of 2,3-, 2,4-disubstituted pyrimido [1,2-a]benzimidazoles, 2,4,10-trisubstituted 2,10-dihydropyrimido [1,2-a]benzimidazoles and 2,3-disubstituted imidazo [2,1-b]benzothiazoles via multicomponent reactions (MCRs) of heterocyclic azoles, aldehydes with easily storable and handling… read more here.
Keywords: pyrimido; benzothiazoles via; diverse synthesis; imidazo benzothiazoles ... See more keywords
Copper-Catalyzed Multicomponent Reactions of Intramolecular and Intermolecular Thiotrifluoromethylation of Alkenes: Access to CF3-Containing 2-Iminothiazolidines and Isothioureas.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02854
Abstract: A copper-catalyzed multicomponent reaction of secondary amines bearing allyl substitution, isothiocyanates, and Togni reagent II has been developed under Cs2CO3 in DCE at 75 °C. An intermolecular multicomponent reaction of thioureas, activated and unactivated alkenes,… read more here.
Keywords: multicomponent reactions; cf3 containing; reactions intramolecular; catalyzed multicomponent ... See more keywords