Disulfide-Directed Multicyclic Peptide Libraries for the Discovery of Peptide Ligands and Drugs.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12462
Abstract: Multicyclic peptides with stable 3D structures are a kind of novel and promising peptide formats for drug design and discovery as they have the potential to combine the best characteristics of small molecules and proteins.… read more here.
Keywords: disulfide directed; multicyclic peptides; directed multicyclic; multicyclic peptide ... See more keywords
Multicyclic Peptides as Scaffolds for the Development of Tumor Targeting Agents.
Sign Up to like & getrecommendations! Published in 2017 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666170316120304
Abstract: The lack of specificity of traditional cytotoxic drugs triggers the development of anticancer agents with high selectivity to tumor-specific proteins. The unveiling of target structures such as EGFR or Her2 allows the focused development of… read more here.
Keywords: scaffolds development; multicyclic peptides; development; display techniques ... See more keywords