Motif-Directed Oxidative Folding to Design and Discover Multicyclic Peptides for Protein Recognition.
Sign Up to like & getrecommendations! Published in 2025 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.5c00060
Abstract: ConspectusMulticyclic peptides that are constrained through covalent cross-linkers can usually maintain stable three-dimensional (3D) structures without the necessity of incorporating noncovalently interacting cores. This configuration allows for a greater utilization of residues for functional purposes… read more here.
Keywords: oxidative folding; multicyclic peptides; disulfide directing; sequence ... See more keywords
Directed Evolution of Multicyclic Peptides Using Yeast Display for Sensitive and Selective Fluorescent Analysis of CD28 on the Cell Surface.
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DOI: 10.1021/acs.analchem.4c05681
Abstract: CD28 is a costimulatory receptor that provides the second signal necessary for T-cell activation and is associated with diseases, including rheumatoid arthritis, asthma, and cancer. Targeting CD28 is crucial for both functional bioanalysis and therapeutic… read more here.
Keywords: cd28; multicyclic peptides; yeast display; sensitive selective ... See more keywords
Disulfide-Directed Multicyclic Peptide Libraries for the Discovery of Peptide Ligands and Drugs.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c12462
Abstract: Multicyclic peptides with stable 3D structures are a kind of novel and promising peptide formats for drug design and discovery as they have the potential to combine the best characteristics of small molecules and proteins.… read more here.
Keywords: disulfide directed; multicyclic peptides; directed multicyclic; multicyclic peptide ... See more keywords
Multicyclic Peptides as Scaffolds for the Development of Tumor Targeting Agents.
Sign Up to like & getrecommendations! Published in 2017 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666170316120304
Abstract: The lack of specificity of traditional cytotoxic drugs triggers the development of anticancer agents with high selectivity to tumor-specific proteins. The unveiling of target structures such as EGFR or Her2 allows the focused development of… read more here.
Keywords: scaffolds development; multicyclic peptides; development; display techniques ... See more keywords