Multifunctional Molecular Beacon Micelles for Intracellular mRNA Imaging and Synergistic Therapy in Multidrug-Resistant Cancer Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Advanced functional materials"
DOI: 10.1002/adfm.201701027
Abstract: Multidrug resistance (MDR) resulting from overexpression of P-glycoprotein (Pgp) transporters increases the drug efflux and thereby limits the chemotherapeutic efficacy. It is desirable to administer both an MDR1 gene silencer and a chemotherapeutic agent in… read more here.
Keywords: multidrug; molecular beacon; dox; multidrug resistant ... See more keywords
Biomimetic Bacteriophage‐Like Particles Formed from Probiotic Extracts and NO Donors for Eradicating Multidrug‐Resistant Staphylococcus aureus
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DOI: 10.1002/adma.202206134
Abstract: Effectively clearing multidrug‐resistant bacteria through nonantibiotic treatments is crucial for the recovery of infected tissues in favorable biological environments. Herein, a thermally responsive donor of cell‐messenger nitric oxide (NO) is combined with extracts of food‐grade… read more here.
Keywords: like particles; multidrug; staphylococcus aureus; multidrug resistant ... See more keywords
Intelligent TAT‐coupled anti‐HER2 immunoliposomes knock downed MDR1 to produce chemosensitize phenotype of multidrug resistant carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.28683
Abstract: Gene therapy using biocompatible cationic liposomes is amongst promising approaches that decreases death from cancers. Here an invasive multidrug resistant cell model has been developed by lentiviral transfection. In parallel phospholipids have been covalently conjugated… read more here.
Keywords: multidrug; tat coupled; coupled anti; intelligent tat ... See more keywords
Red-Light-Responsive Metallopolymer Nanocarriers with Conjugated and Encapsulated Drugs for Phototherapy Against Multidrug-Resistant Tumors.
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DOI: 10.1002/smll.202201672
Abstract: It is challenging to treat multidrug-resistant tumors because such tumors are resistant to a broad spectrum of structurally and functionally unrelated drugs. Herein, treatment of multidrug-resistant tumors using red-light-responsive metallopolymer nanocarriers that are conjugated with… read more here.
Keywords: light responsive; multidrug; multidrug resistant; red light ... See more keywords
Emergence and spread in Taiwan of multidrug-resistant serotypes of nontyphoidal Salmonella
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DOI: 10.1007/s15010-021-01736-0
Abstract: Purpose Antimicrobial resistance of nontyphoidal Salmonella (NTS) is a threat to public health worldwide. Methods A study on longitudinally collected NTS isolates from a medical center in Taiwan from 2011 to 2019 was undertaken. The… read more here.
Keywords: xdr nts; mdr; nontyphoidal salmonella; multidrug ... See more keywords
Occurrence of multidrug-resistant tuberculous meningitis associated with injury during spinal surgery: A case report.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of infection and public health"
DOI: 10.1016/j.jiph.2020.05.022
Abstract: Here we describe a case of multidrug-resistant tuberculous meningitis associated with injury inflicted during spinal surgery. A 54-year-old man was diagnosed with multidrug-resistant spinal tuberculosis (TB). Anterior debridement and fusion with posterior fusion and instrumentation… read more here.
Keywords: resistant tuberculous; multidrug; surgery; multidrug resistant ... See more keywords
Crystallization and characterization of small molecular multidrug resistance inhibitor targeting P-glycoprotein, NSC23925 isomers
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DOI: 10.1016/j.molstruc.2019.05.010
Abstract: Abstract The correlation between P-glycoprotein (Pgp) overexpression and multidrug resistance (MDR) in cancer is well-established. Recently, we identified (2-(4-methoxyphenyl)-4-quinolinyl) (2-piperidinyl)methanol (5) (NSC23925) as the most selective and potent MDR inhibitor. NSC23925 binds to Pgp, thus… read more here.
Keywords: characterization small; multidrug resistance; crystallization characterization; multidrug ... See more keywords
Burden of multidrug and extensively drug-resistant ESKAPEE pathogens in a secondary hospital care setting in Greece
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DOI: 10.1017/s0950268822001492
Abstract: Abstract Bacterial antibiotic resistance (AMR) is a significant threat to public health, with the sentinel ‘ESKAPEE’ pathogens, being of particular concern. A cohort study spanning 5.5 years (2016–2021) was conducted at a provincial general hospital… read more here.
Keywords: eskapee pathogens; mdr; multidrug; hospital ... See more keywords
Structure–Activity Relationships of 8-Hydroxyquinoline-Derived Mannich Bases with Tertiary Amines Targeting Multidrug-Resistant Cancer
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DOI: 10.1021/acs.jmedchem.2c00076
Abstract: A recently proposed strategy to overcome multidrug resistance (MDR) in cancer is to target the collateral sensitivity of otherwise resistant cells. We designed a library of 120 compounds to explore the chemical space around previously… read more here.
Keywords: derived mannich; multidrug; mannich bases; activity ... See more keywords
Naphthylthiazoles: Targeting Multidrug-Resistant and Intracellular Staphylococcus aureus with Biofilm Disruption Activity.
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DOI: 10.1021/acsinfecdis.8b00172
Abstract: Thirty-two new naphthylthiazole derivatives were synthesized with the aim of exploring their antimicrobial effect on multidrug-resistant Gram-positive bacteria. Compounds 25 and 32, with ethylenediamine and methylguanidine side chains, represent the most promising derivatives, as their… read more here.
Keywords: multidrug; naphthylthiazoles targeting; resistant intracellular; multidrug resistant ... See more keywords
A Membrane Curvature Modulated Lipopeptide to Broadly Combat Multidrug-Resistant Bacterial Pneumonia with Low Resistance Risk.
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DOI: 10.1021/acsnano.2c07251
Abstract: The extensive spread of multidrug resistance to Gram-negative bacteria has become a huge threat to human health, where peptide-based antibacterial agents have emerged as a powerful star weapon. Here we report a lipopeptide (LP-20) constructed… read more here.
Keywords: multidrug; membrane curvature; resistance; multidrug resistant ... See more keywords