Trans-envelope multidrug efflux pumps of Gram-negative bacteria and their synergism with the outer membrane barrier.
Sign Up to like & getrecommendations! Published in 2018 at "Research in microbiology"
DOI: 10.1016/j.resmic.2018.02.002
Abstract: Antibiotic resistance is a serious threat to public health. Significant efforts are currently directed toward containment of the spread of resistance, finding new therapeutic options concerning resistant human and animal pathogens, and addressing the gaps… read more here.
Keywords: synergism; outer membrane; multidrug efflux; efflux pumps ... See more keywords
Antibiotic export by MexB multidrug efflux transporter is allosterically controlled by a MexA-OprM chaperone-like complex
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18770-5
Abstract: The tripartite multidrug efflux system MexAB-OprM is a major actor in Pseudomonas aeruginosa antibiotic resistance by exporting a large variety of antimicrobial compounds. Crystal structures of MexB and of its Escherichia coli homolog AcrB had… read more here.
Keywords: antibiotic export; export mexb; mexa; form ... See more keywords
Molecular basis for multidrug efflux by an anaerobic-associated RND transporter
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-65565-7
Abstract: Bacteria can resist antibiotics and toxic substances within demanding ecological settings, such as low oxygen, extreme acid, and during nutrient starvation. MdtEF, a proton motive force-driven efflux pump from the resistance-nodulation-cell division (RND) superfamily, is… read more here.
Keywords: basis multidrug; multidrug; multidrug efflux; transporter ... See more keywords
Structural mass spectrometry approaches to understand multidrug efflux systems
Sign Up to like & getrecommendations! Published in 2022 at "Essays in Biochemistry"
DOI: 10.1042/ebc20220190
Abstract: Abstract Multidrug efflux pumps are ubiquitous across both eukaryotes and prokaryotes, and have major implications in antimicrobial and multidrug resistance. They reside within cellular membranes and have proven difficult to study owing to their hydrophobic… read more here.
Keywords: mass spectrometry; structural mass; efflux; efflux systems ... See more keywords
Regulatory Role of the Two-Component System BasSR in the Expression of the EmrD Multidrug Efflux in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial drug resistance"
DOI: 10.1089/mdr.2019.0412
Abstract: Due to excessive use of antimicrobial agents in the treatment of infectious diseases, bacteria have developed resistance to antibacterial drugs and toxic compounds. The development of multidrug efflux pumps is one of the important mechanisms… read more here.
Keywords: susceptibility; antimicrobial agents; escherichia coli; multidrug efflux ... See more keywords
Biased partitioning of the multidrug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aaf4762
Abstract: Drug efflux machinery inherited asymmetrically In dividing bacterial cells, asymmetric distribution of cell wall constituents occurs between mother cells and their progeny. Asymmetric distribution of efflux machinery in a growing population of bacterial cells results… read more here.
Keywords: multidrug efflux; acrab tolc; long lived; efflux pump ... See more keywords
Interaction of ArmZ with the DNA-Binding Domain of MexZ Induces Expression of mexXY Multidrug Efflux Pump Genes and Antimicrobial Resistance in Pseudomonas aeruginosa
Sign Up to like & getrecommendations! Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01199-19
Abstract: Multidrug efflux pumps play an important role in antibiotic resistance in bacteria. In Pseudomonas aeruginosa, the MexXY pump provides intrinsic resistance to many antimicrobials, including aminoglycosides. The expression of the mexXY operon is negatively regulated… read more here.
Keywords: mexz; expression mexxy; resistance; multidrug efflux ... See more keywords
Structural basis for spermidine recognition and modulation of Acinetobacter baumannii multidrug efflux regulator AmvR
Sign Up to like & getrecommendations! Published in 2025 at "mBio"
DOI: 10.1128/mbio.00081-25
Abstract: ABSTRACT Acinetobacter baumannii is a gram-negative, opportunistic pathogen frequently associated with hospital-acquired infections. Due to its resistance to multiple antibiotics, it is emerging as a major nosocomial pathogen, causing a wide range of severe infections… read more here.
Keywords: amvr; recognition; multidrug efflux; spermidine ... See more keywords
The Multidrug Efflux Regulator AcrR of Escherichia coli Responds to Exogenous and Endogenous Ligands To Regulate Efflux and Detoxification
Sign Up to like & getrecommendations! Published in 2022 at "mSphere"
DOI: 10.1128/msphere.00474-22
Abstract: Multidrug efflux pumps can remove antibiotics and other toxic molecules from cells and are major contributors to antibiotic resistance and bacterial physiology. Therefore, it is essential to better understand their function and regulation. ABSTRACT The… read more here.
Keywords: acrr; physiology; regulator; multidrug efflux ... See more keywords
Host - Bacterial Pathogen Communication: The Wily Role of the Multidrug Efflux Pumps of the MFS Family
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.723274
Abstract: Bacterial pathogens are able to survive within diverse habitats. The dynamic adaptation to the surroundings depends on their ability to sense environmental variations and to respond in an appropriate manner. This involves, among others, the… read more here.
Keywords: multidrug; communication; role multidrug; multidrug efflux ... See more keywords
Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11040520
Abstract: Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by decreasing the intracellular concentration of drugs. This protective barrier consists of a series of transporter proteins, which are located in the bacterial… read more here.
Keywords: efflux pumps; bacterial multidrug; resistance; antimicrobial resistance ... See more keywords