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Published in 2018 at "Research in microbiology"
DOI: 10.1016/j.resmic.2018.02.002
Abstract: Antibiotic resistance is a serious threat to public health. Significant efforts are currently directed toward containment of the spread of resistance, finding new therapeutic options concerning resistant human and animal pathogens, and addressing the gaps…
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Keywords:
synergism;
outer membrane;
multidrug efflux;
efflux pumps ... See more keywords
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Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18770-5
Abstract: The tripartite multidrug efflux system MexAB-OprM is a major actor in Pseudomonas aeruginosa antibiotic resistance by exporting a large variety of antimicrobial compounds. Crystal structures of MexB and of its Escherichia coli homolog AcrB had…
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Keywords:
antibiotic export;
export mexb;
mexa;
form ... See more keywords
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Published in 2022 at "Essays in Biochemistry"
DOI: 10.1042/ebc20220190
Abstract: Abstract Multidrug efflux pumps are ubiquitous across both eukaryotes and prokaryotes, and have major implications in antimicrobial and multidrug resistance. They reside within cellular membranes and have proven difficult to study owing to their hydrophobic…
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Keywords:
mass spectrometry;
structural mass;
efflux;
efflux systems ... See more keywords
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Published in 2020 at "Microbial drug resistance"
DOI: 10.1089/mdr.2019.0412
Abstract: Due to excessive use of antimicrobial agents in the treatment of infectious diseases, bacteria have developed resistance to antibacterial drugs and toxic compounds. The development of multidrug efflux pumps is one of the important mechanisms…
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Keywords:
susceptibility;
antimicrobial agents;
escherichia coli;
multidrug efflux ... See more keywords
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Published in 2017 at "Science"
DOI: 10.1126/science.aaf4762
Abstract: Drug efflux machinery inherited asymmetrically In dividing bacterial cells, asymmetric distribution of cell wall constituents occurs between mother cells and their progeny. Asymmetric distribution of efflux machinery in a growing population of bacterial cells results…
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Keywords:
multidrug efflux;
acrab tolc;
long lived;
efflux pump ... See more keywords
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Published in 2019 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01199-19
Abstract: Multidrug efflux pumps play an important role in antibiotic resistance in bacteria. In Pseudomonas aeruginosa, the MexXY pump provides intrinsic resistance to many antimicrobials, including aminoglycosides. The expression of the mexXY operon is negatively regulated…
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Keywords:
mexz;
expression mexxy;
resistance;
multidrug efflux ... See more keywords
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Published in 2022 at "mSphere"
DOI: 10.1128/msphere.00474-22
Abstract: Multidrug efflux pumps can remove antibiotics and other toxic molecules from cells and are major contributors to antibiotic resistance and bacterial physiology. Therefore, it is essential to better understand their function and regulation. ABSTRACT The…
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Keywords:
acrr;
physiology;
regulator;
multidrug efflux ... See more keywords
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Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.723274
Abstract: Bacterial pathogens are able to survive within diverse habitats. The dynamic adaptation to the surroundings depends on their ability to sense environmental variations and to respond in an appropriate manner. This involves, among others, the…
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Keywords:
multidrug;
communication;
role multidrug;
multidrug efflux ... See more keywords
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Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11040520
Abstract: Multidrug efflux pumps function at the frontline to protect bacteria against antimicrobials by decreasing the intracellular concentration of drugs. This protective barrier consists of a series of transporter proteins, which are located in the bacterial…
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Keywords:
efflux pumps;
bacterial multidrug;
resistance;
antimicrobial resistance ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23147492
Abstract: Multidrug efflux pumps are critical elements in both intrinsic and acquired antibiotic resistance of bacterial populations. Consequently, most studies regarding these protein machineries focus on this specific phenotype. Nevertheless, different works show that efflux pumps…
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Keywords:
efflux pumps;
physiology;
antibiotic resistance;
multidrug efflux ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810856
Abstract: A microcystin-degrading bacterial strain, Blastomonas fulva T2, was isolated from the culture of a microalgae Microcystis. The strain B. fulva T2 is Gram-stain-negative, non-motile, aerobic, non-spore-forming and phototrophic. The cells of B. fulva T2 are…
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Keywords:
microcystin degrading;
genome;
efflux;
new multidrug ... See more keywords