miRNA‐765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells
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DOI: 10.1002/2211-5463.12838
Abstract: Elucidation of the mechanisms underlying multidrug resistance (MDR) is required to ensure the efficacy of chemotherapy against gastric cancer (GC). To investigate this issue, here we identified that microRNA‐765 (miRNA‐765) is up‐regulated both in MDR… read more here.
Keywords: gastric cancer; mirna 765; mdr; multidrug resistance ... See more keywords
Drug Delivery: Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir (Adv. Sci. 2/2018)
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DOI: 10.1002/advs.201870006
Abstract: The sustained release of drug at adequate and stable cytosolic drug concentrations is found to be a feasible scheme to circumvent the multidrug resistance effect and serves as a promising guideline for drug design to… read more here.
Keywords: cytosolic drug; drug; resistance; resistance cancer ... See more keywords
Lemon-Derived Extracellular Vesicles Nanodrugs Enable to Efficiently Overcome Cancer Multidrug Resistance by Endocytosis-Triggered Energy Dissipation and Energy Production Reduction.
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DOI: 10.1002/advs.202105274
Abstract: Multidrug resistance remains a great challenge for cancer chemotherapy. Herein, a biomimetic drug delivery system based on lemon-derived extracellular vesicles (EVs) nanodrugs (marked with heparin-cRGD-EVs-doxorubicin (HRED)) is demonstrated, achieving highly efficient overcoming cancer multidrug resistance.… read more here.
Keywords: cancer; energy; endocytosis; cancer multidrug ... See more keywords
Analysis of mutational history of multidrug‐resistant genotypes with a mutagenetic tree model
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DOI: 10.1002/jmv.28389
Abstract: Human immunodeficiency virus (HIV) can develop resistance to all antiretroviral drugs. Multidrug resistance, however, is a rare event in modern HIV treatment, but can be life‐threatening, particular in patients with very long therapy histories and… read more here.
Keywords: multidrug resistance; resistance; model; analysis mutational ... See more keywords
Chemical molecular‐based approach to overcome multidrug resistance in cancer by targeting P‐glycoprotein (P‐gp)
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DOI: 10.1002/med.21739
Abstract: Multidrug resistance (MDR) remains one of the major impediments for efficacious cancer chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP‐binding cassette (ABC) transporter superfamily is considered one of the primary causes for cancer… read more here.
Keywords: molecular based; chemical molecular; drug; multidrug resistance ... See more keywords
Uncoupler SYP-14288 inducing multidrug resistance of Phytophthora capsici through overexpression of cytochrome P450 monooxygenases and P-glycoprotein.
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DOI: 10.1002/ps.6845
Abstract: BACKGROUND Fungicide resistance has become a serious problem for different mode of action groups except for uncouplers, which makes their resistance mechanism a hot topic. Until now, it has not been well clarified. SYP-14288, a… read more here.
Keywords: syp 14288; multidrug resistance; phytophthora capsici; p450 ... See more keywords
NIR Activated Multimodal Therapeutics Based on Metal-Phenolic Networks-Functionalized Nanoplatform for Combating against Multidrug Resistance and Metastasis.
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DOI: 10.1002/smll.202206174
Abstract: Multidrug resistance (MDR) and metastasis in cancer have become increasingly serious problems since antitumor efficiency is greatly restricted by a single therapeutic modality and the insensitive tumor microenvironment (TME). Herein, metal-phenolic network-functionalized nanoparticles (t-P@TFP NPs)… read more here.
Keywords: metastasis; activated multimodal; nir activated; multidrug resistance ... See more keywords
In vivo characterization of [18F]AVT-011 as a radiotracer for PET imaging of multidrug resistance
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04589-w
Abstract: Multidrug resistance (MDR) impedes cancer treatment. Two efflux transporters from the ATP-binding cassette (ABC) family, ABCB1 and ABCG2, may contribute to MDR by restricting the entry of therapeutic drugs into tumor cells. Although a higher… read more here.
Keywords: 18f avt; avt 011; pet imaging; multidrug resistance ... See more keywords
Reversion of Multidrug Resistance by Co-Encapsulation of Doxorubicin and Metformin in Poly(lactide-co-glycolide)-d-α-tocopheryl Polyethylene Glycol 1000 Succinate Nanoparticles
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DOI: 10.1007/s11095-018-2404-7
Abstract: PurposeP-glycoprotein (P-gp) mediated multidrug resistance (MDR) has been recognized as the main obstacle against successful cancer treatment. To address this problem, co-encapsulated doxorubicin (DOX) and metformin (Met) in a biodegradable polymer composed of poly(lactide-co-glycolide) (PLGA)… read more here.
Keywords: tocopheryl polyethylene; poly lactide; lactide glycolide; dox ... See more keywords
BAG family proteins contributes to autophagy-mediated multidrug resistance of tumor
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DOI: 10.1007/s12094-022-02819-6
Abstract: Multidrug resistance (MDR) is a significant cause of tumor treatment failure. Accumulating evidence suggests that autophagy plays a significant role in the development of MDR. Autophagy is a conserved mechanism that maintains tumor homeostasis by… read more here.
Keywords: tumor; family proteins; multidrug resistance; bag family ... See more keywords
Characterization of multidrug resistance in Vibrio species isolated from marine invertebrates from Andaman Sea
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DOI: 10.1007/s13205-020-02445-5
Abstract: This study describes the abundance of multidrug-resistant Vibrios associated with marine invertebrate hosts from the Andaman Sea, India. Thirty-eight Vibrio strains were isolated from surface mucus layers of coral Porites, Goniastrea, Pocillopora, Fungia, and eggs… read more here.
Keywords: vibrio; andaman sea; multidrug resistance;