miRNA‐765 mediates multidrug resistance via targeting BATF2 in gastric cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.12838
Abstract: Elucidation of the mechanisms underlying multidrug resistance (MDR) is required to ensure the efficacy of chemotherapy against gastric cancer (GC). To investigate this issue, here we identified that microRNA‐765 (miRNA‐765) is up‐regulated both in MDR… read more here.
Keywords: gastric cancer; mirna 765; mdr; multidrug resistance ... See more keywords
Drug Delivery: Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir (Adv. Sci. 2/2018)
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Science"
DOI: 10.1002/advs.201870006
Abstract: The sustained release of drug at adequate and stable cytosolic drug concentrations is found to be a feasible scheme to circumvent the multidrug resistance effect and serves as a promising guideline for drug design to… read more here.
Keywords: cytosolic drug; drug; resistance; resistance cancer ... See more keywords
Lemon-Derived Extracellular Vesicles Nanodrugs Enable to Efficiently Overcome Cancer Multidrug Resistance by Endocytosis-Triggered Energy Dissipation and Energy Production Reduction.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202105274
Abstract: Multidrug resistance remains a great challenge for cancer chemotherapy. Herein, a biomimetic drug delivery system based on lemon-derived extracellular vesicles (EVs) nanodrugs (marked with heparin-cRGD-EVs-doxorubicin (HRED)) is demonstrated, achieving highly efficient overcoming cancer multidrug resistance.… read more here.
Keywords: cancer; energy; endocytosis; cancer multidrug ... See more keywords
Novel Folate–Phenylfuran P‐gp Inhibitor Conjugates for Overcoming Multidrug Resistance in MCF‐7/ADR Cell
Sign Up to like & getrecommendations! Published in 2025 at "ChemMedChem"
DOI: 10.1002/cmdc.202500216
Abstract: P‐glycoprotein (P‐gp) functions as a critical membrane transporter that drives tumor resistance by mediating drug efflux, ultimately contributing to multidrug resistance (MDR). Recently potent inhibitors have shown significant potential in countering chemotherapeutic resistance, particularly in… read more here.
Keywords: resistance; mcf adr; folate; cell ... See more keywords
Evodiamine Enhances Chemosensitivity in Colorectal Cancer by Targeting Ribonucleotide Reductase M2
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70541
Abstract: Currently, chemotherapy in colorectal cancer (CRC) often leads to the development of drug resistance and poor prognosis. Prior research has shown that Evodiamine (Evo) exhibits antitumor properties; however, it has not been well studied in… read more here.
Keywords: colorectal cancer; cancer; evodiamine enhances; evo ... See more keywords
Analysis of mutational history of multidrug‐resistant genotypes with a mutagenetic tree model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28389
Abstract: Human immunodeficiency virus (HIV) can develop resistance to all antiretroviral drugs. Multidrug resistance, however, is a rare event in modern HIV treatment, but can be life‐threatening, particular in patients with very long therapy histories and… read more here.
Keywords: multidrug resistance; resistance; model; analysis mutational ... See more keywords
Chemical molecular‐based approach to overcome multidrug resistance in cancer by targeting P‐glycoprotein (P‐gp)
Sign Up to like & getrecommendations! Published in 2020 at "Medicinal Research Reviews"
DOI: 10.1002/med.21739
Abstract: Multidrug resistance (MDR) remains one of the major impediments for efficacious cancer chemotherapy. Increased efflux of multiple chemotherapeutic drugs by transmembrane ATP‐binding cassette (ABC) transporter superfamily is considered one of the primary causes for cancer… read more here.
Keywords: molecular based; chemical molecular; drug; multidrug resistance ... See more keywords
Uncoupler SYP-14288 inducing multidrug resistance of Phytophthora capsici through overexpression of cytochrome P450 monooxygenases and P-glycoprotein.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.6845
Abstract: BACKGROUND Fungicide resistance has become a serious problem for different mode of action groups except for uncouplers, which makes their resistance mechanism a hot topic. Until now, it has not been well clarified. SYP-14288, a… read more here.
Keywords: syp 14288; multidrug resistance; phytophthora capsici; p450 ... See more keywords
NIR Activated Multimodal Therapeutics Based on Metal-Phenolic Networks-Functionalized Nanoplatform for Combating against Multidrug Resistance and Metastasis.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202206174
Abstract: Multidrug resistance (MDR) and metastasis in cancer have become increasingly serious problems since antitumor efficiency is greatly restricted by a single therapeutic modality and the insensitive tumor microenvironment (TME). Herein, metal-phenolic network-functionalized nanoparticles (t-P@TFP NPs)… read more here.
Keywords: metastasis; activated multimodal; nir activated; multidrug resistance ... See more keywords
In vivo characterization of [18F]AVT-011 as a radiotracer for PET imaging of multidrug resistance
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04589-w
Abstract: Multidrug resistance (MDR) impedes cancer treatment. Two efflux transporters from the ATP-binding cassette (ABC) family, ABCB1 and ABCG2, may contribute to MDR by restricting the entry of therapeutic drugs into tumor cells. Although a higher… read more here.
Keywords: 18f avt; avt 011; pet imaging; multidrug resistance ... See more keywords
First-in-human evaluation of 6-bromo-7-[11C]methylpurine, a PET tracer for assessing the function of multidrug resistance-associated proteins in different tissues
Sign Up to like & getrecommendations! Published in 2024 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-024-06851-2
Abstract: Multidrug resistance-associated protein 1 (MRP1) is a transport protein with a widespread tissue distribution, which has been implicated in the pathophysiology of Alzheimer’s and chronic respiratory disease. PET with 6-bromo-7-[11C]methylpurine ([11C]BMP) has been used to… read more here.
Keywords: function; resistance associated; different tissues; pet ... See more keywords