Hypovitaminosis D and reduced cathelicidin are strongly correlated during the multidrug therapy against leprosy.
Sign Up to like & getrecommendations! Published in 2020 at "Microbial pathogenesis"
DOI: 10.1016/j.micpath.2020.104373
Abstract: Mycobacterium leprae infection depends on the competence of the host immune defense to induce effective protection against this intracellular pathogen. The present study investigated the serum levels of vitamin D and the antimicrobial peptide cathelicidin,… read more here.
Keywords: hypovitaminosis reduced; reduced cathelicidin; multidrug therapy; strongly correlated ... See more keywords
Effect of multidrug therapy on the prognosis of Mycobacterium avium complex pulmonary disease
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DOI: 10.1038/s41598-024-55135-0
Abstract: Multidrug therapy for Mycobacterium avium complex pulmonary disease (MAC-PD) results in negative sputum cultures. However, the prognostic value of this treatment approach remains unclear. This study aimed to clarify whether multidrug therapy reduces the incidence… read more here.
Keywords: multidrug therapy; observation group; group; group 1000 ... See more keywords
The Dapsone Conundrum: Understanding Implications of Adverse Reactions to Dapsone Including Dapsone Hypersensitivity Syndrome in Leprosy Patients Treated With Multidrug Therapy
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Dermatology"
DOI: 10.1111/ijd.17906
Abstract: The introduction of the World Health Organization's multidrug therapy (WHO‐MDT) has significantly advanced leprosy treatment. Although dapsone is a fundamental component of MDT, it presents risks of adverse drug reactions (ADR), including the potentially fatal… read more here.
Keywords: dapsone; multidrug therapy; dapsone hypersensitivity; hypersensitivity syndrome ... See more keywords
Diagnosis and impact of neuropathic pain in leprosy patients in Nepal after completion of multidrug therapy
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0006610
Abstract: Objectives Neuropathic pain (NP) can occur as a chronic complication of leprosy neuropathy. NP epidemiology and its impact on patients have not been well documented. This study investigates NP prevalence and impact in the years… read more here.
Keywords: completion; impact; multidrug therapy; neuropathic pain ... See more keywords
Leprosy relapse after multidrug therapy: Systematic review and meta-analysis
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DOI: 10.1371/journal.pntd.0011870
Abstract: Objective To synthesize the scientific evidence regarding the prevalence of leprosy relapse following multidrug therapy. Method A systematic review was conducted following the JBI methodology for prevalence studies and reported according to the guidelines, with… read more here.
Keywords: leprosy relapse; relapse; multidrug therapy; meta analysis ... See more keywords
Cocrystallizing and Codelivering Complementary Drugs to MultidrugResistant Tuberculosis Bacteria in Perfecting Multidrug Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026623666230504094521
Abstract: Bacteria cells exhibit multidrug resistance in one of two ways: by raising the genetic expression of multidrug efflux pumps or by accumulating several drug-resistant components in many genes. Multidrug-resistive tuberculosis bacteria are treated by multidrug… read more here.
Keywords: drug; resistance; multidrug therapy; tuberculosis bacteria ... See more keywords
Efficacy of fixed duration multidrug therapy for the treatment of multibacillary leprosy: A prospective observational study from Northern India.
Sign Up to like & getrecommendations! Published in 2022 at "Indian journal of dermatology, venereology and leprology"
DOI: 10.25259/ijdvl_915_2021
Abstract: Background In endemic regions of several countries, the prevalence of leprosy has not come down to the level of elimination. On the contrary, new cases are being detected in large numbers. Clinically, it is frequently… read more here.
Keywords: therapy treatment; completion; multidrug therapy; therapy ... See more keywords
Mycobacterium leprae-Specific Antibodies in Multibacillary Leprosy Patients Decrease During and After Treatment With Either the Regular 12 Doses Multidrug Therapy (MDT) or the Uniform 6 Doses MDT
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.00915
Abstract: Leprosy serology reflects the bacillary load of patients and multidrug therapy (MDT) reduces Mycobacterium leprae-specific antibody titers of multibacillary (MB) patients. The Clinical Trial for Uniform Multidrug Therapy Regimen for Leprosy Patients in Brazil (U-MDT/CT-BR)… read more here.
Keywords: mdt; leprae specific; serology; multidrug therapy ... See more keywords