Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO)
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DOI: 10.1038/s41598-018-25139-8
Abstract: Trimethylamine-N-oxide (TMAO) gained considerable attention because of its role as a cardiovascular risk biomarker. Organic cation transporter 2 (OCT2) mediates TMAO uptake into renal proximal tubular cells. Here we investigated the potential role of multidrug… read more here.
Keywords: mdck oct2; multidrug toxin; trimethylamine oxide; oxide tmao ... See more keywords
Impact of Direction of Transport on the Evaluation of Substrate Recognition of Mouse Multidrug and Toxin Extrusion Protein 1
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DOI: 10.1124/dmd.122.001115
Abstract: Multidrug and toxin extrusion protein (MATE/SLC47A) secretes metabolites and xenobiotics into the urine in the proximal tubules of the kidney. Uptake assays have been commonly used for evaluating MATE-mediated transport of new chemical entities in… read more here.
Keywords: toxin extrusion; kidney; drug; multidrug toxin ... See more keywords