Cellular expression and function of naturally occurring variants of the human ABCG2 multidrug transporter
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03186-2
Abstract: The human ABCG2 multidrug transporter plays a crucial role in the absorption and excretion of xeno- and endobiotics; thus the relatively frequent polymorphic and mutant ABCG2 variants in the population may significantly alter disease conditions… read more here.
Keywords: multidrug transporter; abcg2 multidrug; expression; function ... See more keywords
The reliability of molecular dynamics simulations of the multidrug transporter P-glycoprotein in a membrane environment
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0191882
Abstract: Despite decades of research, the mechanism of action of the ABC multidrug transporter P-glycoprotein (P-gp) remains elusive. Due to experimental limitations, many researchers have turned to molecular dynamics simulation studies in order to investigate different… read more here.
Keywords: multidrug transporter; membrane environment; molecular dynamics; transporter glycoprotein ... See more keywords
Selective Fluorescent Probes for High-Throughput Functional Diagnostics of the Human Multidrug Transporter P-Glycoprotein (ABCB1)
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231810599
Abstract: The multidrug transporter ABCB1 (MDR1, Pgp) plays an important role in the absorption, distribution, metabolism, and elimination of a wide range of pharmaceutical compounds. Functional investigation of the ABCB1 expression is also essential in many… read more here.
Keywords: multidrug transporter; transporter; probes high; high throughput ... See more keywords