Molecular insights into the multifaceted functions and therapeutic targeting of high mobility group box 1 in metabolic diseases
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DOI: 10.1111/jcmm.17448
Abstract: HMGB1 is a ubiquitously expressed protein localized in nucleus, cytoplasm, as well as secreted into extracellular space. Nuclear HMGB1 binds to DNAs and RNAs, regulating genomic stability and transcription. Cytoplasmic HMGB1 regulates autophagy through binding… read more here.
Keywords: molecular insights; metabolic diseases; insights multifaceted; functions therapeutic ... See more keywords
Putting Together Pieces of the Lateral Septum: Multifaceted Functions and Its Neural Pathways
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DOI: 10.1523/eneuro.0315-21.2021
Abstract: Abstract The lateral septum (LS) is implicated as a hub that regulates a variety of affects, such as reward, feeding, anxiety, fear, sociability, and memory. However, it remains unclear how the LS, previously treated as… read more here.
Keywords: pieces lateral; multifaceted functions; putting together; together pieces ... See more keywords
Multifaceted Functions of Protein Kinase D in Pathological Processes and Human Diseases
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DOI: 10.3390/biom11030483
Abstract: Protein kinase D (PKD) is a family of serine/threonine protein kinases operating in the signaling network of the second messenger diacylglycerol. The three family members, PKD1, PKD2, and PKD3, are activated by a variety of… read more here.
Keywords: human diseases; pathological processes; multifaceted functions; protein kinase ... See more keywords
ZNF224 Protein: Multifaceted Functions Based on Its Molecular Partners
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DOI: 10.3390/molecules26206296
Abstract: The transcription factor ZNF224 is a Kruppel-like zinc finger protein that consists of 707 amino acids and contains 19 tandemly repeated C2H2 zinc finger domains that mediate DNA binding and protein–protein interactions. ZNF224 was originally… read more here.
Keywords: repressor; znf224 protein; zinc finger; multifaceted functions ... See more keywords