The multifaceted role of extracellular vesicles in metastasis: Priming the soil for seeding
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Cancer"
DOI: 10.1002/ijc.30595
Abstract: Extracellular vesicles (EVs), including exosomes, play a key role in inter and intracellular communication, promoting the proliferation and invasion of recipient cells to support tumor growth and metastasis. Metastasis comprises multiple steps that first include… read more here.
Keywords: extracellular vesicles; metastasis; role; cancer ... See more keywords
The multifaceted role of periostin in priming the tumor microenvironments for tumor progression
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2646-2
Abstract: Tumor microenvironment consists of tumor cells, stromal cells, extracellular matrix and a plethora of soluble components. The complex array of interactions between tumor cells and their surrounding tumor microenvironments contribute to the determination of the… read more here.
Keywords: role periostin; multifaceted role; tumor microenvironments; tumor ... See more keywords
The multifaceted role of plasminogen in inflammation
Sign Up to like & getrecommendations! Published in 2020 at "Cellular Signalling"
DOI: 10.1016/j.cellsig.2020.109761
Abstract: A fine-tuned activation and deactivation of proteases and their inhibitors are involved in the execution of the inflammatory response. The zymogen/proenzyme plasminogen is converted to the serine protease plasmin, a key fibrinolytic factor by plasminogen… read more here.
Keywords: plasminogen; role plasminogen; inflammation; inflammatory response ... See more keywords
Oil does more than light the lamp: The multifaceted role of lipids in thermogenic fat.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.04.018
Abstract: Brown and beige adipocytes, or thermogenic fat, were initially thought to be merely a thermogenic organ. However, emerging evidence suggests its multifaceted roles in the regulation of systemic glucose and lipid homeostasis that go beyond… read more here.
Keywords: role lipids; lipids thermogenic; oil light; thermogenic fat ... See more keywords
A multifaceted role for MOF histone modifying factor in genome maintenance
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2016.03.012
Abstract: MOF (males absent on the first) was initially identified as a dosage compensation factor in Drosophila that acetylates lysine 16 of histone H4 (H4K16ac) and increased gene transcription from the single copy male X-chromosome. In… read more here.
Keywords: role mof; mof; multifaceted role; factor ... See more keywords
The multifaceted role of GCM1 during trophoblast differentiation in the human placenta
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2203071119
Abstract: Significance Proper placental development is critical for pregnancy success. Placental maldevelopment is linked with serious pregnancy complications that jeopardize the health of both mother and child. The parenchymal cells of the placenta are trophoblasts, which… read more here.
Keywords: gcm1 trophoblast; role; trophoblast differentiation; gcm1 ... See more keywords
The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications
Sign Up to like & getrecommendations! Published in 2020 at "Brain"
DOI: 10.1093/brain/awaa022
Abstract: By reviewing recent findings on kinase function in ALS, Guo et al. show that kinases are implicated in ALS disease progression on three levels: a) genes encoding kinases are causal or risk genes in ALS;… read more here.
Keywords: kinases amyotrophic; role kinases; amyotrophic lateral; sclerosis genetic ... See more keywords
A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses
Sign Up to like & getrecommendations! Published in 2021 at "Life Science Alliance"
DOI: 10.26508/lsa.202000874
Abstract: Progranulin deficiency leads to decreased levels of human APP and Aβ in a sex- and age-dependent manner and enhanced inflammatory and lysosomal responses in the plaque-associated microglia. Haploinsufficiency of progranulin (PGRN) is a leading cause… read more here.
Keywords: progranulin regulating; role progranulin; progranulin; pgrn ... See more keywords
Understanding the Multifaceted Role of Neutrophils in Cancer and Autoimmune Diseases
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02456
Abstract: Neutrophils are one of the first immune cell types that are recruited to injury and infection site. As a vital component of the immune system, neutrophils are heterogeneous immune cells known to have phagocytic property… read more here.
Keywords: understanding multifaceted; cancer autoimmune; autoimmune diseases; neutrophils cancer ... See more keywords
Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.897688
Abstract: Retromer is a highly integrated multimeric protein complex that mediates retrograde cargo sorting from endosomal compartments. In concert with its accessory proteins, the retromer drives packaged cargoes to tubular and vesicular structures, thereby transferring them… read more here.
Keywords: retromer; misdelivery multifaceted; beware misdelivery; multifaceted role ... See more keywords
Ferroptosis and Its Multifaceted Role in Cancer: Mechanisms and Therapeutic Approach
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11081504
Abstract: Ferroptosis, a new type of non-apoptotic cell death modality, is different from other modes of cell death and has been primarily found in tumor cells. Previous studies have reported that ferroptosis can be triggered by… read more here.
Keywords: mechanisms therapeutic; iron; multifaceted role; ferroptosis ... See more keywords