PBMDR: A particle swarm optimization-based multifactor dimensionality reduction for the detection of multilocus interactions.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2018.10.012
Abstract: Studies on multilocus interactions have mainly investigated the associations between genetic variations from the related genes and histopathological tumor characteristics in patients. However, currently, the identification and characterization of susceptibility genes for complex diseases remain… read more here.
Keywords: swarm optimization; based multifactor; particle swarm; optimization ... See more keywords
Fuzzy-Based Multiobjective Multifactor Dimensionality Reduction for Epistasis Analysis
Sign Up to like & getrecommendations! Published in 2022 at "IEEE/ACM Transactions on Computational Biology and Bioinformatics"
DOI: 10.1109/tcbb.2022.3144303
Abstract: Epistasis detection is vital for understanding disease susceptibility in genetics. Multiobjective multifactor dimensionality reduction (MOMDR) was previously proposed to detect epistasis. MOMDR was performed using binary classification to distinguish the high-risk (H) and low-risk (L)… read more here.
Keywords: classification; fuzzy; epistasis; multifactor dimensionality ... See more keywords
Synergistic influence of cytokine gene polymorphisms over the risk of dementia: A multifactor dimensionality reduction analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.952173
Abstract: Objective Evidence supports the important role of neuroinflammation in some types of dementia. This study aimed to evaluate the effect of epistasis of gene cytokines such as interleukin (IL)-α, IL-6, tumor necrosis factor (TNFα), and… read more here.
Keywords: dimensionality reduction; analysis; multifactor dimensionality; gene ... See more keywords