2‐Hydroxy‐4‐benzyloxylimine Resveratrol Derivatives as Potential Multifunctional Agents for the Treatment of Parkinson's Disease
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DOI: 10.1002/cmdc.202200629
Abstract: A series of 2‐hydroxy‐4‐benzyloxylimine resveratrol derivatives was designed, synthesized and evaluated as multifunctional agents for the treatment of Parkinson's disease. The results revealed that most derivatives possessed good multifunctional activities. Among them, representative compound (E)‐5‐[(4‐fluorobenzyl)oxy]‐2‐{[(4‐hydroxyphenyl)imino]methyl}phenol… read more here.
Keywords: disease; benzyloxylimine resveratrol; parkinson disease; hydroxy benzyloxylimine ... See more keywords
Novel salicylamide derivatives as potent multifunctional agents for the treatment of Alzheimer's disease: Design, synthesis and biological evaluation.
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DOI: 10.1016/j.bioorg.2018.11.022
Abstract: A series of salicylamide derivatives were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease. In vitro assays demonstrated that most of the derivatives were selective AChE inhibitors. They showed good… read more here.
Keywords: alzheimer disease; treatment; salicylamide derivatives; agents treatment ... See more keywords
Semi-synthesis and biological evaluation of flavone hybrids as multifunctional agents for the potential treatment of Alzheimer's disease.
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DOI: 10.1016/j.bioorg.2020.103917
Abstract: 7-O-galloyltricetiflavan (GTF), a natural flavonoid, is known to exert anti-oxidation and neuroprotective activity, which are related to the prevention of Alzheimer's disease (AD). In this study, three series of GTF hybrids have been designed, synthesized… read more here.
Keywords: semi synthesis; alzheimer disease; treatment; synthesis biological ... See more keywords
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.12.009
Abstract: A series of aurone Mannich base derivatives were designed, synthesized and evaluated as multifunctional agents for the treatment of Alzheimer's disease. In vitro assays demonstrated that most of the derivatives were selective AChE inhibitors with good… read more here.
Keywords: mannich base; alzheimer disease; aurone mannich; base derivatives ... See more keywords
Multifunctional agents based on benzoxazolone as promising therapeutic drugs for diabetic nephropathy.
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DOI: 10.1016/j.ejmech.2021.113269
Abstract: Diabetic nephropathy (DN) is resulted from activations of polyol pathway and oxidative stress by abnormal metabolism of glucose, and no specific medication is available. We designed a novel class of benzoxazolone derivatives, and a number… read more here.
Keywords: polyol pathway; based benzoxazolone; benzoxazolone; diabetic nephropathy ... See more keywords
New Multifunctional Agents for Potential Alzheimer’s Disease Treatment Based on Tacrine Conjugates with 2-Arylhydrazinylidene-1,3-Diketones
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DOI: 10.3390/biom12111551
Abstract: Alzheimer’s disease (AD) is considered a modern epidemic because of its increasing prevalence worldwide and serious medico-social consequences, including the economic burden of treatment and patient care. The development of new effective therapeutic agents for… read more here.
Keywords: agents potential; disease; alzheimer disease; new multifunctional ... See more keywords
New Multifunctional Agents Based on Conjugates of 4-Amino-2,3-polymethylenequinoline and Butylated Hydroxytoluene for Alzheimer’s Disease Treatment
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DOI: 10.3390/molecules25245891
Abstract: New hybrids of 4-amino-2,3-polymethylenequinoline with different sizes of the aliphatic ring linked to butylated hydroxytoluene (BHT) by enaminoalkyl (7) or aminoalkyl (8) spacers were synthesized as potential multifunctional agents for Alzheimer’s disease (AD) treatment. All… read more here.
Keywords: alzheimer disease; disease; butylated hydroxytoluene; amino polymethylenequinoline ... See more keywords