Metal-chelating benzothiazole multifunctional compounds for the modulation and 64Cu PET imaging of Aβ aggregation†
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DOI: 10.1039/d0sc02641g
Abstract: While Alzheimer's Disease (AD) is the most common neurodegenerative disease, there is still a dearth of efficient therapeutic and diagnostic agents for this disorder. Reported herein are a series of new multifunctional compounds (MFCs) with… read more here.
Keywords: modulation; aggregation; metal chelating; multifunctional compounds ... See more keywords
On the Chemical and Biological Characteristics of Multifunctional Compounds for the Treatment of Parkinson’s Disease
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DOI: 10.3390/antiox12020214
Abstract: Protein aggregation, mitochondrial dysfunction, iron dyshomeostasis, increased oxidative damage and inflammation are pathognomonic features of Parkinson’s disease (PD) and other neurodegenerative disorders characterized by abnormal iron accumulation. Moreover, the existence of positive feed-back loops between… read more here.
Keywords: multifunctional compounds; disease; iron; capacity ... See more keywords
Development of Dibenzothiazepine Derivatives as Multifunctional Compounds for Neuropathic Pain
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DOI: 10.3390/ph15040407
Abstract: Neuropathic pain is a chronic and sometimes intractable condition caused by lesions or diseases of the somatosensory nervous system. Many drugs are available but unfortunately do not provide satisfactory effects in patients, producing limited analgesia… read more here.
Keywords: pain; dibenzothiazepine derivatives; multifunctional compounds; neuropathic pain ... See more keywords