Designing a new multifunctional peptide for metal chelation and Aβ inhibition.
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.06.004
Abstract: According to the Amyloid hypothesis, as the foremost scientific explanation for Alzheimer Disease (AD), the neuropathology of AD is related to toxic fragments of amyloid beta (Aβ) protein. Based on this hypothesis, an attractive therapeutic… read more here.
Keywords: chelation; new multifunctional; multifunctional peptide; metal ... See more keywords
Delivering Multifunctional Peptide-Conjugated Gene Carrier/miRNA-218 Complexes from Monodisperse Microspheres for Bone Regeneration.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c10728
Abstract: MicroRNAs (miRNAs) play a pivotal role in regulating gene expression and are considered new molecular targets in bone tissue engineering. However, effective delivery of miRNAs to the defect areas and transfection of the miRNAs into… read more here.
Keywords: ppp rgi; 218 complexes; mir 218; multifunctional peptide ... See more keywords
Low Fouling Protein Detection in Complex Biological Media Supported by a Designed Multifunctional Peptide.
Sign Up to like & getrecommendations! Published in 2018 at "ACS sensors"
DOI: 10.1021/acssensors.8b00318
Abstract: The construction of sensitive and selective biosensors capable of detecting specific targets in complex biological samples remains a challenge highly relevant to a range of sensor/diagnostic applications. Herein, we have utilized a multifunctional peptide to… read more here.
Keywords: fouling protein; peptide; detection; multifunctional peptide ... See more keywords
Multifunctional peptide-assembled micelles for simultaneously reducing amyloid-β and reactive oxygen species†
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Science"
DOI: 10.1039/d1sc00153a
Abstract: The excessive production and deposition of amyloid-β (Aβ) is one of the most important etiologies of Alzheimer's disease (AD). The interaction between Aβ and metal ions produces aberrant reactive oxygen species (ROS), which induce oxidative… read more here.
Keywords: reactive oxygen; peptide assembled; oxygen species; multifunctional peptide ... See more keywords
Discovery of a Multifunctional Octapeptide from Lingzhi with Antioxidant and Tyrosinase Inhibitory Activity
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15060684
Abstract: Ganoderma lucidum or Lingzhi is a fungus species widely known as a traditional medicine. Exploring the beneficial peptides by hydrolysis using pepsin and trypsin has been extensively performed to identify new bioactive natural products. A… read more here.
Keywords: discovery multifunctional; multifunctional octapeptide; tyrosinase; activity ... See more keywords