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   Articles with "multigene panel" as a keyword



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Multigene panel testing for hereditary breast and ovarian cancer in the province of Ontario

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recommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"

DOI: 10.1007/s00432-020-03377-6

Abstract: Purpose The aim of this study was to determine the diagnostic yield of multigene panel testing among patients referred with hereditary breast and ovarian cancer (HBOC). Methods Patients who met provincial eligibility criteria were tested… read more here.

Keywords: multigene panel; breast ovarian; panel testing; cancer ... See more keywords
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Multigene panel testing in unselected Israeli breast cancer cases: mutational spectrum and use of BRCA1/2 mutation prediction algorithms

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recommendations! Published in 2019 at "Breast Cancer Research and Treatment"

DOI: 10.1007/s10549-019-05228-6

Abstract: BackgroundStudies assessing the contribution of non-BRCA1/2 gene mutations to inherited breast cancer (BC) predisposition consistently reported low (up to 4%) yield. The current study aimed at assessing the spectrum of non-BRCA mutations in unselected Israeli… read more here.

Keywords: multigene panel; brca1; breast cancer; panel testing ... See more keywords
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Uncertainty related to multigene panel testing for cancer: a qualitative study on counsellors’ and counselees’ views

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recommendations! Published in 2018 at "Journal of Community Genetics"

DOI: 10.1007/s12687-018-0393-1

Abstract: Multigene panel testing is mainly used to improve identification of genetic causes in families with characteristics fitting multiple possible cancer syndromes. This technique may yield uncertainty, for example when variants of unknown significance are identified.… read more here.

Keywords: uncertainty; multigene panel; study; panel testing ... See more keywords
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Impact of Multigene Panel Testing on Surgical Decision Making in Breast Cancer Patients.

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recommendations! Published in 2018 at "Journal of the American College of Surgeons"

DOI: 10.1016/j.jamcollsurg.2017.12.037

Abstract: BACKGROUND With the advent of multigene panel testing for breast cancer patients, germline mutations with unknown association with cancer risk, known as variants of uncertain significance (VUS), are being increasingly identified. Some studies have shown… read more here.

Keywords: multigene panel; breast cancer; panel testing; cancer ... See more keywords
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Determination of the etiology of pediatric urinary stone disease by multigene panel and metabolic screening evaluation.

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recommendations! Published in 2021 at "Journal of pediatric urology"

DOI: 10.1016/j.jpurol.2021.03.028

Abstract: INTRODUCTION Urinary tract stone disease (UTSD) is seen with increasing frequency in children, and genetic, metabolic and environmental factors are known to play a role in its etiology. Since it is a genetically heterogeneous disease,… read more here.

Keywords: etiology; multigene panel; disease; evaluation ... See more keywords
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Cancer worry, genetic knowledge, and attitudes towards NGS multigene panel testing among Korean breast cancer patients

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recommendations! Published in 2019 at "Annals of Oncology"

DOI: 10.1093/annonc/mdz434.005

Abstract: Abstract Background Recent advances in next generation sequencing technology helped us to test multiple germline genetic mutations simultaneously. However, because of the low frequency of pathogenic/ likely pathogenic variants beyond BRCA1/2, modest risk of cancer… read more here.

Keywords: panel; multigene panel; breast cancer; cancer worry ... See more keywords
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Pre‐analytical processing protocol of breast biopsies affects multigene panel results

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recommendations! Published in 2022 at "International Journal of Experimental Pathology"

DOI: 10.1111/iep.12444

Abstract: The creation of multigene panels for prognostic and predictive purposes allows a more accurate indication of adjuvant chemotherapy for patients with breast cancer. In a previous study, we reproduced a multigene panel of 21 genes… read more here.

Keywords: multigene panel; analytical processing; breast; panel ... See more keywords
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Costs associated with the use of multigene panel tests in three solid tumor types and the impact on insurance premiums.

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recommendations! Published in 2023 at "Future oncology"

DOI: 10.2217/fon-2023-0094

Abstract: Aim: This study assessed the costs associated with multigene panel tests (MGPTs) in the USA and the impact of coverage on insurance premiums. Materials & methods: We conducted a retrospective claims analysis to estimate total… read more here.

Keywords: multigene panel; panel tests; three solid; costs associated ... See more keywords
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Alignment of health plan coverage policies for somatic multigene panel testing with clinical guidelines in select solid tumors.

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recommendations! Published in 2022 at "Personalized medicine"

DOI: 10.2217/pme-2021-0174

Abstract: Aim: Commercial plan coverage policies for multigene panel tests may vary and could result in geographic variation in coverage due to the fragmented nature of the commercial insurance market. This study aimed to characterize the alignment… read more here.

Keywords: plan coverage; multigene panel; coverage; clinical guidelines ... See more keywords
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Molecular Characterization of Pancreatic Ductal Adenocarcinoma Using a Next-Generation Sequencing Custom-Designed Multigene Panel

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recommendations! Published in 2022 at "Diagnostics"

DOI: 10.3390/diagnostics12051058

Abstract: Despite the efforts made in the management of PDAC, the 5-year relative survival rate of pancreatic ductal adenocarcinoma (PDAC) still remains very low (10%). To date, precision oncology is far from being ready to be… read more here.

Keywords: multigene panel; ductal adenocarcinoma; panel; next generation ... See more keywords
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Hereditary Gastric Cancer: Single-Gene or Multigene Panel Testing? A Mono-Institutional Experience

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recommendations! Published in 2023 at "Genes"

DOI: 10.3390/genes14051077

Abstract: Gastric cancer (GC) has long been a ‘Cinderella’ among hereditary cancers. Until recently, single-gene testing (SGT) was the only approach to identify high-risk individuals. With the spread of multigene panel testing (MGPT), a debate arose… read more here.

Keywords: multigene panel; mono institutional; gastric cancer; panel testing ... See more keywords