Enantiopure ethyl 2,3-dibromopropionate: Enantioselective synthesis vs preparative HPLC enantioseparation of racemate on multigram scale.
Sign Up to like & getrecommendations! Published in 2020 at "Chirality"
DOI: 10.1002/chir.23260
Abstract: Racemic ethyl 2,3-dibromopropionate, commercially available at low price, is a key intermediate used in the synthesis of several heterocycle fragments, which are present in many biologically active compounds. Surprisingly, the enantiomers are not commercially available… read more here.
Keywords: enantioseparation; ethyl dibromopropionate; racemate; multigram scale ... See more keywords
Stereoselective Multigram-Scale Tn Antigen Synthesis via the Iron-Catalyzed Glycal 1,2-cis-Aminoglycosylation
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DOI: 10.1021/acs.orglett.5c01560
Abstract: We report here a new catalytic and exclusively cis-selective glycosylation strategy for multigram scale synthesis of biologically valuable Tn antigens. The underlying iron-catalyzed glycal 1,2-cis-aminoglycosylation method is effective with a variety of galactosyl donors and… read more here.
Keywords: catalyzed glycal; glycal cis; cis aminoglycosylation; synthesis ... See more keywords