Robustness and lethality in multilayer biological molecular networks
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-19841-3
Abstract: Robustness is a prominent feature of most biological systems. Most previous related studies have been focused on homogeneous molecular networks. Here we propose a comprehensive framework for understanding how the interactions between genes, proteins and… read more here.
Keywords: robustness lethality; multilayer biological; layer; lethality multilayer ... See more keywords
Deep learning identifies explainable reasoning paths of mechanism of action for drug repurposing from multilayer biological network
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac469
Abstract: The discovery and repurposing of drugs require a deep understanding of the mechanism of drug action (MODA). Existing computational methods mainly model MODA with the protein-protein interaction (PPI) network. However, the molecular interactions of drugs… read more here.
Keywords: network; drug repurposing; biological network; deep learning ... See more keywords