Multilevel virtual screening approach for discovery of thymidine phosphorylase inhibitors as potential anticancer agents
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131648
Abstract: Abstract Thymidine phosphorylase (TP) is an enzyme which catalyses the conversion of thymidine to thymine and 2-deoxy-α- d -ribose-1-phosphate. The 2-deoxy-α- d -ribose-1-phosphate is then dephosphorylated to the 2-deoxy-α- d -ribose, which can promote angiogenesis,… read more here.
Keywords: thymidine phosphorylase; virtual screening; thymidine; multilevel virtual ... See more keywords
Accelerating Scaffold Hopping in Fourth-Generation Epidermal Growth Factor Receptor Inhibitors via Multilevel Virtual Screening.
Sign Up to like & getrecommendations! Published in 2025 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.5c00194
Abstract: The epidermal growth factor receptor (EGFR) family plays a crucial role in regulating cell proliferation, apoptosis, and differentiation. However, challenges related to drug resistance have emerged in the clinical applications of this family. This study… read more here.
Keywords: virtual screening; factor receptor; growth factor; multilevel virtual ... See more keywords