Synthesis of multimeric pyrrolidine iminosugar inhibitors of human β-glucocerebrosidase and α-galactosidase A: First example of a multivalent enzyme activity enhancer for Fabry disease.
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DOI: 10.1016/j.ejmech.2020.112173
Abstract: The synthesis of a chemical library of multimeric pyrrolidine-based iminosugars by incorporation of three pairs of epimeric pyrrolidine-azides into different alkyne scaffolds via CuAAC is presented. The new multimers were evaluated as inhibitors of two… read more here.
Keywords: enzyme activity; first example; fabry disease; multimeric pyrrolidine ... See more keywords