Branched short elastin‐like peptides with temperature responsiveness obtained by EDTA‐mediated multimerization
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DOI: 10.1002/psc.3449
Abstract: Elastin‐like peptides (ELPs) exhibit a reversible phase transition, known as coacervation, triggered by temperature changes. This property makes them useful as stimuli‐responsive molecular materials for various applications. Among ELPs, short peptide chain lengths have some… read more here.
Keywords: like peptides; elastin like; temperature; multimerization ... See more keywords
Melinjo seed extract increases adiponectin multimerization in physiological and pathological conditions
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DOI: 10.1038/s41598-020-61148-2
Abstract: Melinjo seed extract (MSE) contains large amounts of polyphenols, including dimers of trans-resveratrol ( e.g. gnetin C, L, gnemonoside A, B and D), and has been shown to potentially improve obesity. However, there is no… read more here.
Keywords: multimerization; seed; mse; melinjo seed ... See more keywords
Stochastic protein multimerization, activity, and fitness.
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DOI: 10.1103/physreve.98.062401
Abstract: Many proteins assemble into homomultimeric structures, with a number of subunits that can vary substantially among phylogenetic lineages. As protein-protein interactions require productive encounters among subunits, such variation might partially be explained by variation in… read more here.
Keywords: protein; multimerization; multimerization activity; stochastic protein ... See more keywords
A Conformational Escape Reaction of HIV-1 against an Allosteric Integrase Inhibitor
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.00486-20
Abstract: Understanding the mechanism of HIV-1 resistance to anti-HIV-1 drugs could lead to the development of novel drugs with increased efficiency, resulting in more effective ART. ART composed of more potent and long-acting anti-HIV-1 drugs can… read more here.
Keywords: anti hiv; hiv drugs; hiv; hiv rna ... See more keywords
Abstract 561: Discovery of a potential best-in-class anti-CD38 therapeutic utilizing Fc multimerization
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-561
Abstract: CD38 targeting antibodies are at different phases of clinical development, with daratumumab already approved as monotherapy and in combination with standards of care in multiple myeloma (MM). Anti-CD38 monoclonal antibodies (mAbs) induce tumor cell depletion… read more here.
Keywords: sifbody; multimerization; cd38; cell ... See more keywords
Structural basis of Von Willebrand Factor multimerization and tubular storage.
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DOI: 10.1182/blood.2021014729
Abstract: The von Willebrand factor (VWF) propeptide (domains D1D2), is essential for the assembly of VWF multimers and its tubular storage in Weibel-Palade bodies. However, detailed molecular mechanism underlying this propeptide dependence is unclear. Here we… read more here.
Keywords: willebrand factor; multimerization; storage; von willebrand ... See more keywords
The N-Terminal α-Helix of Potato Virus X-Encoded RNA-Dependent RNA Polymerase Is Required for Membrane Association and Multimerization
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DOI: 10.3390/v14091907
Abstract: Positive-sense single-stranded RNA viruses replicate in virus-induced membranous organelles for maximum efficiency and immune escaping. The replication of potato virus X (PVX) takes place on the endoplasmic reticulum (ER); however, how PVX-encoded RNA-dependent RNA polymerase… read more here.
Keywords: rna; potato virus; association; virus ... See more keywords
Multimerization of the GATA4 transcription factor regulates transcriptional activity and cardiomyocyte hypertrophic response
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DOI: 10.7150/ijbs.65664
Abstract: The activation of the GATA-binding factor 4 (GATA4) transcription factor induces cardiac hypertrophy and heart failure. The multimerization of transcription factors often plays an important role in the regulation of transcriptional activity. Here, we report… read more here.
Keywords: transcription factor; multimerization; gata4; gata4 transcription ... See more keywords