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   Articles with "multiple ascending" as a keyword



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P306 MORF-057, an oral selective α4β7 integrin inhibitor for Inflammatory Bowel Disease, leads to specific target engagement in a single and multiple ascending dose study in healthy subjects

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recommendations! Published in 2021 at "Journal of Crohn's and Colitis"

DOI: 10.1093/ecco-jcc/jjab076.430

Abstract: MORF-057 is an orally administered small molecule designed to inhibit the α 4β 7 receptor, addressing an unmet medical need in inflammatory bowel disease (IBD) patients, and avoiding the need for periodic therapeutic infusions and the risk… read more here.

Keywords: inflammatory bowel; morf 057; single multiple; study ... See more keywords
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A randomized single and multiple ascending dose study in healthy volunteers of LTI‐291, a centrally penetrant glucocerebrosidase activator

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recommendations! Published in 2021 at "British Journal of Clinical Pharmacology"

DOI: 10.1111/bcp.14772

Abstract: A mutation in the GBA1 gene is the most common genetic risk factor for developing Parkinson's disease. GBA1 encodes the lysosomal enzyme glucosylceramidase beta (glucocerebrosidase, GCase) and mutations decrease enzyme activity. LTI‐291 is an allosteric… read more here.

Keywords: randomized single; glucocerebrosidase; single multiple; lti 291 ... See more keywords

Phase I Single Ascending Dose and Food Effect Study in Healthy Adults and Phase I/IIa Multiple Ascending Dose Study in Patients with Pulmonary Tuberculosis to Assess Pharmacokinetics, Bactericidal Activity, Tolerability, and Safety of OPC-167832

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recommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.01477-22

Abstract: OPC-167832, an inhibitor of decaprenylphosphoryl-β-d-ribose 2’-oxidase, demonstrated potent antituberculosis activity and a favorable safety profile in preclinical studies. This report describes the first two clinical studies of OPC-167832: (i) a phase I single ascending dose… read more here.

Keywords: single ascending; opc 167832; ascending dose; activity ... See more keywords