Bayesian methods to compare dose levels with placebo in a small n, sequential, multiple assignment, randomized trial.
Sign Up to like & getrecommendations! Published in 2020 at "Statistics in medicine"
DOI: 10.1002/sim.8813
Abstract: Clinical trials studying treatments for rare diseases are challenging to design and conduct due to the limited number of patients eligible for the trial. One design used to address this challenge is the small n,… read more here.
Keywords: trial; multiple assignment; small sequential; treatment ... See more keywords
Comparing adaptive interventions under a general sequential multiple assignment randomized trial design via multiple comparisons with the best
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Statistical Planning and Inference"
DOI: 10.1016/j.jspi.2020.06.008
Abstract: Abstract This paper considers screening of adaptive interventions or adaptive treatment strategies embedded in a sequential multiple assignment randomized trial (SMART). As a SMART typically consists of numerous adaptive interventions, inferential procedures based on pairwise… read more here.
Keywords: trial; multiple assignment; adaptive interventions; randomized trial ... See more keywords
Interim monitoring in sequential multiple assignment randomized trials.
Sign Up to like & getrecommendations! Published in 2021 at "Biometrics"
DOI: 10.1111/biom.13562
Abstract: A sequential multiple assignment randomized trial (SMART) facilitates the comparison of multiple adaptive treatment strategies (ATSs) simultaneously. Previous studies have established a framework to test the homogeneity of multiple ATSs by a global Wald test… read more here.
Keywords: multiple assignment; monitoring sequential; interim monitoring; sequential multiple ... See more keywords
Efficient and robust approaches for analysis of sequential multiple assignment randomized trials: Illustration using the ADAPT-R trial.
Sign Up to like & getrecommendations! Published in 2022 at "Biometrics"
DOI: 10.1111/biom.13808
Abstract: Personalized intervention strategies, in particular those that modify treatment based on a participant's own response, are a core component of precision medicine approaches. Sequential multiple assignment randomized trials (SMARTs) are growing in popularity and are… read more here.
Keywords: sequential multiple; adapt trial; assignment randomized; multiple assignment ... See more keywords
Interim monitoring of sequential multiple assignment randomized trials using partial information.
Sign Up to like & getrecommendations! Published in 2022 at "Biometrics"
DOI: 10.1111/biom.13854
Abstract: The sequential multiple assignment randomized trial (SMART) is the gold standard trial design to generate data for the evaluation of multi-stage treatment regimes. As with conventional (single-stage) randomized clinical trials, interim monitoring allows early stopping;… read more here.
Keywords: sequential multiple; interim monitoring; assignment randomized; using partial ... See more keywords
Sample size considerations for comparing dynamic treatment regimens in a sequential multiple-assignment randomized trial with a continuous longitudinal outcome
Sign Up to like & getrecommendations! Published in 2019 at "Statistical Methods in Medical Research"
DOI: 10.1177/0962280219877520
Abstract: Clinicians and researchers alike are increasingly interested in how best to personalize interventions. A dynamic treatment regimen is a sequence of prespecified decision rules which can be used to guide the delivery of a sequence… read more here.
Keywords: multiple assignment; trial; randomized trial; sequential multiple ... See more keywords