The risk of progression to type 1 diabetes is highly variable in individuals with multiple autoantibodies following screening
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DOI: 10.1007/s00125-019-05047-w
Abstract: Aims/hypothesis Young children who develop multiple autoantibodies (mAbs) are at very high risk for type 1 diabetes. We assessed whether a population with mAbs detected by screening is also at very high risk, and how… read more here.
Keywords: risk type; risk; age; multiple autoantibodies ... See more keywords
Longitudinal Pattern of First-Phase Insulin Response Is Associated With Genetic Variants Outside the Class II HLA Region in Children With Multiple Autoantibodies
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DOI: 10.2337/db19-0329
Abstract: A declining first-phase insulin response (FPIR) is associated with positivity for multiple islet autoantibodies, irrespective of class II HLA DR-DQ genotype. We examined the associations of FPIR with genetic variants outside the HLA DR-DQ region… read more here.
Keywords: class; genetic variants; hla region; multiple autoantibodies ... See more keywords
Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study.
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DOI: 10.2337/dc21-2612
Abstract: OBJECTIVE To distinguish among predictors of seroconversion, progression to multiple autoantibodies and from multiple autoantibodies to type 1 diabetes in young children. RESEARCH DESIGN AND METHODS Genetically high-risk newborns (n = 8,502) were followed for… read more here.
Keywords: progression; islet; type diabetes; progression multiple ... See more keywords