EGCG sensitizes chemotherapeutic-induced cytotoxicity by targeting the ERK pathway in multiple cancer cell lines.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108546
Abstract: Epigallocatechin-3-gallate (EGCG), a major polyphenol component of green tea, presents anticancer efficacy. However, its exact mechanism of action is not known. In this study, we evaluated the effect of EGCG alone or in combination with… read more here.
Keywords: cell lines; egcg; cancer cell; cancer ... See more keywords
Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06366-x
Abstract: In this study we use somatic cancer mutations to identify important functional residues within sets of related genes. We focus on protein kinases, a superfamily of phosphotransferases that share homologous sequences and structural motifs and… read more here.
Keywords: cancer; cancer types; multiple cancer; loss function ... See more keywords
Abstract 2185: Efficacy of Rac/Cdc42 inhibitors in multiple cancer models
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs18-2185
Abstract: The RhoGTPases Rac and Cdc42 are excellent therapeutic targets for inhibiting metastasis because these homologous proteins regulate numerous cellular functions that promote tumorigenesis, angiogenesis, invasion and therefore, metastasis. Also, Rac1, Cdc42, and their effector p21-activated… read more here.
Keywords: cdc42; cancer; multiple cancer; rac cdc42 ... See more keywords
SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models.
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DOI: 10.1158/2159-8290.cd-18-0444
Abstract: Adaptive resistance to MEK inhibitors (MEKi) typically occurs via induction of genes for different receptor tyrosine kinases (RTK) and/or their ligands, even in tumors of the same histotype, making combination strategies challenging. SHP2 (PTPN11) is… read more here.
Keywords: mek inhibitors; adaptive resistance; resistance; cancer ... See more keywords
Multiple cancer pathways regulate telomere protection
Sign Up to like & getrecommendations! Published in 2019 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201910292
Abstract: Telomeres are considered as universal anti‐cancer targets, as telomere maintenance is essential to sustain indefinite cancer growth. Mutations in telomerase, the enzyme that maintains telomeres, are among the most frequently found in cancer. In addition,… read more here.
Keywords: telomere protection; cancer pathways; pathways regulate; regulate telomere ... See more keywords
Genetic alteration and clinical significance of SUMOylation regulators in multiple cancer types
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer"
DOI: 10.7150/jca.49042
Abstract: The purpose of this study was to investigate the genetic variation, gene expression differences, and clinical significance of SUMOylation regulators in pan-cancers. Based on previous studies, we gained a better understanding of the biological process… read more here.
Keywords: sumoylation; sumoylation regulators; cancer; clinical significance ... See more keywords
PRL3 as a therapeutic target for novel cancer immunotherapy in multiple cancer types
Sign Up to like & getrecommendations! Published in 2023 at "Theranostics"
DOI: 10.7150/thno.79265
Abstract: Phosphatase of Regenerating Liver-3 (PRL3) was discovered in 1998 and was subsequently found to be correlated with cancer progression and metastasis in 2001. Extensive research in the past two decades has produced significant findings on… read more here.
Keywords: prl3; immunotherapy; cancer types; multiple cancer ... See more keywords