Low frequency of POLD1 and POLE exonuclease domain variants in patients with multiple colorectal polyps
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.603
Abstract: Germline mutations affecting the exonuclease domains of POLE and POLD1 predispose to colorectal adenomas and carcinoma. Here, we aimed to screen the exonuclease domains to find the genetic causes of multiple colorectal polyps in unexplained… read more here.
Keywords: exonuclease; colorectal polyps; low frequency; multiple colorectal ... See more keywords
Multiple colorectal adenomas in Lynch syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1038678
Abstract: Background Lynch syndrome has not traditionally been considered to have a high colorectal adenoma burden. However, with increasing adenoma detection rates in the general population, the incidence of adenoma detection in Lynch syndrome may also… read more here.
Keywords: adenomas; adenoma; adenomas lynch; lynch syndrome ... See more keywords