Pharmacokinetics and Pharmacodynamics of Lansoprazole/Sodium Bicarbonate Immediate-release Capsules in Healthy Chinese Subjects: An Open, Randomized, Controlled, Crossover, Single-, and Multiple-dose Trial.
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DOI: 10.1002/cpdd.1251
Abstract: Proton pump inhibitors (PPIs) differ in onset of action and bioavailability. This trial was conducted to investigate the pharmacokinetics and pharmacodynamics of an immediate-release capsule formulation containing lansoprazole 30 mg and sodium bicarbonate 1100 mg (T preparation)… read more here.
Keywords: lansoprazole sodium; single multiple; pharmacokinetics pharmacodynamics; preparation ... See more keywords
Single‐ and Multiple‐Dose Safety, Tolerability, and Pharmacokinetic Profiles of ASP8062: Results From 2 Phase 1 Studies
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DOI: 10.1002/cpdd.766
Abstract: ASP8062 is an orally active γ‐amino‐butyric acid type B (GABAB) receptor positive allosteric modulator currently in phase 2 development. Safety and pharmacokinetic (PK) profiles of ASP8062 were evaluated in 2 studies in healthy subjects. The… read more here.
Keywords: profiles asp8062; pharmacokinetic profiles; safety; single multiple ... See more keywords
Pharmacokinetics, Pharmacodynamics, and Tolerability of Concomitant Multiple Dose Administration of Verinurad (RDEA3170) and Allopurinol in Adult Male Subjects With Gout
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DOI: 10.1002/jcph.1119
Abstract: Verinurad (RDEA3170) is a selective uric acid reabsorption inhibitor in clinical development for treatment of hyperuricemia and gout. This phase 1b, multiple‐dose, drug‐drug interaction study evaluated the pharmacokinetics, pharmacodynamics, and tolerability of verinurad in combination… read more here.
Keywords: verinurad allopurinol; verinurad; multiple dose; pharmacodynamics tolerability ... See more keywords
Comparison of Pharmacokinetics and Safety of Ranolazine PR between Koreans and Caucasians.
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DOI: 10.1016/j.clinthera.2021.01.005
Abstract: PURPOSE Ranolazine, an inhibitor of late inward sodium current, is an antianginal agent. In this study, the pharmacokinetic (PK) properties and tolerability of single- and multiple-dose ranolazine were compared between healthy Koreans and Caucasians. METHODS… read more here.
Keywords: ranolazine; difference; koreans caucasians; safety ... See more keywords
Results of two Phase 1, Randomized, Double-blind, Placebo-controlled, Studies (Ascending Single-Dose and Multiple-Dose Studies) to Determine the Safety, Tolerability, and Pharmacokinetics of Orally Administered LX9211 in Healthy Participants.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2021.04.014
Abstract: PURPOSE For neuropathic pain, current therapies do not provide relief for most patients; less than half achieve a 50% pain reduction. Current analgesics have adverse effects. We present 2 Phase I studies of LX9211, a… read more here.
Keywords: lx9211; controlled studies; placebo controlled; multiple dose ... See more keywords
A Phase I, Multiple-Dose, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Pharmacokinetics, Safety, and Tolerability of Etelcalcetide Administered Intravenously to Chinese Patients With Chronic Kidney Disease Undergoing Hemodialysis.
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DOI: 10.1016/j.clinthera.2021.09.019
Abstract: PURPOSE This study reports data from the first evaluation of etelcalcetide treatment in Chinese adults with chronic kidney disease and secondary hyperparathyroidism. METHODS This phase I, randomized study compared thrice-weekly etelcalcetide (5 mg per dose… read more here.
Keywords: etelcalcetide administered; chronic kidney; treatment; study ... See more keywords
Multiple-dose clinical pharmacology of ACT-541468, a novel dual orexin receptor antagonist, following repeated-dose morning and evening administration
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DOI: 10.1016/j.euroneuro.2019.05.009
Abstract: ACT-541468 is a dual orexin receptor antagonist with sleep-promoting effects in humans. Following entry-into-humans, its pharmacokinetics (PK) including dose-proportionality and accumulation, pharmacodynamics (PD), safety, and tolerability following multiple-ascending oral dose (MAD) administration in the morning,… read more here.
Keywords: evening administration; pharmacology; act 541468; multiple dose ... See more keywords
The influence of Javanese turmeric (Curcuma xanthorrhiza) on the pharmacokinetics of warfarin in rats with single and multiple-dose studies
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DOI: 10.1080/13880209.2021.1928716
Abstract: Abstract Context Co-administration between warfarin (WF) and Curcuma xanthorrhiza Roxb. (Zingiberaceae) (CX) is found in Indonesian patients and need to be evaluated. Objective This study assesses the effect of concomitant administration of CX extract on… read more here.
Keywords: day; administration; curcuma xanthorrhiza; multiple dose ... See more keywords
Effects of ginkgo leaf tablet on the pharmacokinetics of rosiglitazone in rats and its potential mechanism
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DOI: 10.1080/13880209.2022.2087688
Abstract: Abstract Context Ginkgo leaf tablet (GLT), a traditional Chinese herbal formula, is often combined with rosiglitazone (ROS) for type 2 diabetes mellitus treatment. However, the drug-drug interaction between GLT and ROS remains unknown. Objective To… read more here.
Keywords: leaf tablet; dose glt; multiple dose; ginkgo leaf ... See more keywords
Successful treatment of potentially lethal dose thallium sulfate poisoning with sequential use of Prussian blue and multiple-dose activated charcoal
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DOI: 10.1080/15563650.2023.2165502
Abstract: Thallium poisoning is rare but associated with considerable morbidity and mortality, with lethal doses reported between 8 and 12mg/kg [1]. We report a case of full recovery following treatment of an ingestion of thallium sulfate… read more here.
Keywords: day; thallium; thallium sulfate; multiple dose ... See more keywords
Multiple-Dose Oral Fosfomycin for Treatment of Complicated Urinary Tract Infections in the Outpatient Setting
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DOI: 10.1093/ofid/ofaa034
Abstract: Abstract Background Few published studies exist to describe the off-label use of multiple-dose fosfomycin for outpatient treatment of complicated urinary tract infections (UTI). The purpose of this study was to characterize the patients, infections, drug… read more here.
Keywords: resolution; dose fosfomycin; treatment; multiple dose ... See more keywords