Pharmacokinetics of multiple doses of transdermal flunixin meglumine in adult Holstein dairy cows.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of veterinary pharmacology and therapeutics"
DOI: 10.1111/jvp.12490
Abstract: A transdermal formulation of the nonsteroidal anti-inflammatory drug, flunixin meglumine, has been approved in the United States and Canada for single-dose administration. Transdermal flunixin meglumine was administered to 10 adult Holstein cows in their second… read more here.
Keywords: flunixin meglumine; adult holstein; transdermal flunixin; multiple doses ... See more keywords
Oral Fosfomycin Efficacy with Variable Urinary Exposures following Single and Multiple Doses against Enterobacterales: the Importance of Heteroresistance for Growth Outcome
Sign Up to like & getrecommendations! Published in 2020 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01982-19
Abstract: Oral fosfomycin trometamol is licensed as a single oral dose for the treatment of uncomplicated urinary tract infections, with activity against multidrug-resistant uropathogens. The impact of interindividual variability in urinary concentrations on antimicrobial efficacy, and… read more here.
Keywords: urinary exposures; efficacy; multiple doses; fosfomycin ... See more keywords
KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers
Sign Up to like & getrecommendations! Published in 2017 at "Orphanet Journal of Rare Diseases"
DOI: 10.1186/s13023-017-0715-0
Abstract: BackgroundMitochondrial disorders are a clinically, biochemically and genetically heterogeneous group of multi-system diseases, with an unmet medical need for treatment. KH176 is an orally bio-available small molecule under development for the treatment of mitochondrial(−related) diseases.… read more here.
Keywords: healthy male; clinical trial; trial; male volunteers ... See more keywords
Pharmacokinetics of amantadine after oral administration of single and multiple doses to orange-winged Amazon parrots (Amazona amazonica).
Sign Up to like & getrecommendations! Published in 2020 at "American journal of veterinary research"
DOI: 10.2460/ajvr.81.8.651
Abstract: OBJECTIVE To determine the pharmacokinetics of amantadine after oral administration of single and multiple doses to orange-winged Amazon parrots (Amazona amazonica). ANIMALS 12 adult orange-winged Amazon parrots (6 males and 6 females). PROCEDURES A single… read more here.
Keywords: amazon parrots; orange winged; winged amazon; multiple doses ... See more keywords
Multiple doses of SHR-1222, a sclerostin monoclonal antibody, in postmenopausal women with osteoporosis: A randomized, double-blind, placebo-controlled, dose-escalation phase 1 trial
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1168757
Abstract: SHR-1222, a novel humanized monoclonal antibody targeting sclerostin, has been shown to induce bone formation and decrease bone resorption at a single dose ranging 50–400 mg in our previous phase 1 trial. This study was… read more here.
Keywords: bone; doses shr; placebo; phase trial ... See more keywords
Baicalin Enhanced Oral Bioavailability of Sorafenib in Rats by Inducing Intestine Absorption
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.761763
Abstract: Background: Sorafenib (SOR) is an oral, potent, selective, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used as the first-line therapy for advanced hepatocellular carcinoma (HCC). Baicalin (BG) is used as adjuvant therapy for… read more here.
Keywords: absorption; oral bioavailability; enhanced oral; intestine absorption ... See more keywords
Impact of Perioperative Multiple Doses of Glucocorticoids on Peripheral Blood Lymphocyte Subsets and Inflammatory Cytokines in Patients With Non-small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Surgery"
DOI: 10.3389/fsurg.2022.859984
Abstract: Purpose Surgery-induced immunosuppression is associated with infectious complications and cancer recurrence. This study aimed to characterize the effects of perioperative multiple doses of glucocorticoids on the peripheral immune environment in patients with non-small cell lung… read more here.
Keywords: lung cancer; cell; perioperative multiple; doses glucocorticoids ... See more keywords