Some remaining challenges regarding multiple endpoints in clinical trials.
Sign Up to like & getrecommendations! Published in 2017 at "Statistics in medicine"
DOI: 10.1002/sim.7390
Abstract: Despite recent advance in methods for handling multiple endpoints in clinical trials, some challenges remain. This paper discusses some of these challenges, including confusion surrounding the terminology used to describe the multiple endpoints, the justification… read more here.
Keywords: regarding multiple; endpoints clinical; challenges regarding; clinical trials ... See more keywords
Statistical planning in confirmatory clinical trials with multiple treatment groups, multiple visits, and multiple endpoints
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2017.1378664
Abstract: ABSTRACT Multiplicity issues can be multidimensional: A confirmatory clinical trial may be designed to have efficacy assessed with two or more primary endpoints, for multiple dose groups, and at several post-baseline visits. Controlling for multiplicity… read more here.
Keywords: multiplicity; confirmatory clinical; higher dose; multiple visits ... See more keywords
A cluster-adjusted rank-based test for a clinical trial concerning multiple endpoints with application to dietary intervention assessment.
Sign Up to like & getrecommendations! Published in 2019 at "Biometrics"
DOI: 10.1111/biom.13029
Abstract: Multiple endpoints are often naturally clustered based on their scientific interpretations. Tests that compare these clustered outcomes between independent groups may lose efficiency if the cluster structures are not properly accounted for. For the two-sample… read more here.
Keywords: multiple endpoints; dietary intervention; concerning multiple; cluster ... See more keywords