A hybrid stochastic-deterministic approach to explore multiple infection and evolution in HIV
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1009713
Abstract: To study viral evolutionary processes within patients, mathematical models have been instrumental. Yet, the need for stochastic simulations of minority mutant dynamics can pose computational challenges, especially in heterogeneous systems where very large and very… read more here.
Keywords: hybrid stochastic; infection; stochastic deterministic; cell ... See more keywords
Beneficial effects of cellular coinfection resolve inefficiency in influenza A virus transcription
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010865
Abstract: For diverse viruses, cellular infection with single vs. multiple virions can yield distinct biological outcomes. We previously found that influenza A/guinea fowl/Hong Kong/WF10/99 (H9N2) virus (GFHK99) displays a particularly high reliance on multiple infection in… read more here.
Keywords: multiple infection; effects cellular; transcription; infection ... See more keywords