Molecular phenotyping of multiple mouse strains under metabolic challenge uncovers a role for Elovl2 in glucose-induced insulin secretion
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2017.01.009
Abstract: Objective In type 2 diabetes (T2D), pancreatic β cells become progressively dysfunctional, leading to a decline in insulin secretion over time. In this study, we aimed to identify key genes involved in pancreatic beta cell… read more here.
Keywords: insulin; insulin secretion; mouse strains; multiple mouse ... See more keywords
Modeling diseases in multiple mouse strains for precision medicine studies.
Sign Up to like & getrecommendations! Published in 2017 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00123.2016
Abstract: The genetic basis of the phenotypic variability observed in patients can be studied in mice by generating disease models through genetic or chemical interventions in many genetic backgrounds where the clinical phenotypes can be assessed… read more here.
Keywords: medicine; diseases multiple; mouse strains; modeling diseases ... See more keywords