TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas
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DOI: 10.1158/1078-0432.ccr-21-0312
Abstract: Purpose: The epigenetic mechanisms involved in transcriptional regulation leading to malignant phenotype in gliomas remains poorly understood. Topoisomerase IIB (TOP2B), an enzyme that decoils and releases torsional forces in DNA, is overexpressed in a subset… read more here.
Keywords: human gliomas; oncogenes human; glioma; multiple oncogenes ... See more keywords