Generation of hyperlipidemic rabbit models using multiple sgRNAs targeted CRISPR/Cas9 gene editing system
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DOI: 10.1186/s12944-019-1013-8
Abstract: ObjectiveTo generate novel rabbit models with a large-fragment deletion of either LDL receptor (LDLR) and/or apolipoprotein (apoE) genes for the study of hyperlipidemic and atherosclerosis.MethodsCRISPR/Cas9 system directed by a multiple sgRNAs system was used in… read more here.
Keywords: system; ldlr apoe; rabbit models; multiple sgrnas ... See more keywords