Molecular modeling of C1‐inhibitor as SARS‐CoV‐2 target identified from the immune signatures of multiple tissues: An integrated bioinformatics study
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3769
Abstract: The expeditious transmission of the severe acute respiratory coronavirus 2 (SARS‐CoV‐2), a strain of COVID‐19, crumbled the global economic strength and caused a veritable collapse in health infrastructure. The molecular modeling of the novel coronavirus… read more here.
Keywords: molecular modeling; gene; multiple tissues; sars cov ... See more keywords
Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues
Sign Up to like & getrecommendations! Published in 2020 at "GeroScience"
DOI: 10.1007/s11357-020-00185-1
Abstract: An increase in the burden of senescent cells in tissues with age contributes to driving aging and the onset of age-related diseases. Genetic and pharmacologic elimination of senescent cells extends both health span and life… read more here.
Keywords: senescence; parabiosis regulates; multiple tissues; heterochronic parabiosis ... See more keywords
Identification and analysis of splicing quantitative trait loci across multiple tissues in the human genome
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-020-20578-2
Abstract: Alternative splicing (AS) is a fundamental step in eukaryotic mRNA biogenesis. Here, we develop an efficient and reproducible pipeline for the discovery of genetic variants that affect AS (splicing QTLs, sQTLs). We use it to… read more here.
Keywords: analysis splicing; across multiple; identification analysis; human genome ... See more keywords
SAT-552 Oxidative Stress Induces Type 3 Deiodinase on Multiple Tissues in Disease: Implications to Nonthyroidal Illness Syndrome Pathophysiology
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Endocrine Society"
DOI: 10.1210/js.2019-sat-552
Abstract: Abstract Imbalances in the redox status are involved in type 3 deiodinase (D3) induction in the non-thyroidal illness syndrome (NTIS). The mechanisms responsible for D3 dysfunction under systemic redox alterations in disease are poorly understood.… read more here.
Keywords: illness syndrome; type deiodinase; multiple tissues; induction ... See more keywords
Author Response: In Vivo Distribution of α-Synuclein in Multiple Tissues and Biofluids in Parkinson Disease
Sign Up to like & getrecommendations! Published in 2021 at "Neurology"
DOI: 10.1212/wnl.0000000000011938
Abstract: Regarding the sensitivity of IHC aSyn methods in participants with idiopathic REM sleep behavioral disorder (RBD), we agree that these are encouraging for the early detection of α-synucleinopathies but point out that not all participants… read more here.
Keywords: vivo distribution; response vivo; author response; synuclein multiple ... See more keywords
Network Embedding Across Multiple Tissues and Data Modalities Elucidates the Context of Host Factors Important for COVID-19 Infection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.909714
Abstract: COVID-19 is a heterogeneous disease caused by SARS-CoV-2. Aside from infections of the lungs, the disease can spread throughout the body and damage many other tissues, leading to multiorgan failure in severe cases. The highly… read more here.
Keywords: network; disease; covid; across multiple ... See more keywords
Predicting N6-Methyladenosine Sites in Multiple Tissues of Mammals through Ensemble Deep Learning
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415490
Abstract: N6-methyladenosine (m6A) is the most abundant within eukaryotic messenger RNA modification, which plays an essential regulatory role in the control of cellular functions and gene expression. However, it remains an outstanding challenge to detect mRNA… read more here.
Keywords: ensemble deep; deep learning; m6a; methyladenosine ... See more keywords