M28 Polygenic Risk For BIP, MDD, And SCZ In Andalusian Multiplex Families
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2016.09.419
Abstract: Background Recent large-scale genome-wide association studies (GWAS) have successfully identified common genetic variations contributing to the risk for psychiatric disorders, such as major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SCZ). It has been… read more here.
Keywords: risk; mdd scz; multiplex families; mdd ... See more keywords
Psychiatric symptoms and syndromes transcending diagnostic boundaries in Indian multiplex families: The cohort of ADBS study
Sign Up to like & getrecommendations! Published in 2021 at "Psychiatry Research"
DOI: 10.1016/j.psychres.2020.113647
Abstract: Syndromes of schizophrenia, bipolar disorder, obsessive-compulsive disorder, substance use disorders and Alzheimer's dementia are highly heritable. About 10-20% of subjects have another affected first degree relative (FDR), and thus represent a 'greater' genetic susceptibility. We… read more here.
Keywords: multiplex families; symptoms syndromes; transcending diagnostic; psychiatric symptoms ... See more keywords
Longitudinal study of narcolepsy symptoms in first, second, and third-degree relatives of simplex and multiplex narcolepsy families.
Sign Up to like & getrecommendations! Published in 2019 at "Sleep medicine"
DOI: 10.1016/j.sleep.2018.06.015
Abstract: OBJECTIVE To assess the evolution of narcolepsy symptoms in first-, second, and third-degree relatives and to compare multiplex and simplex families. METHODS A total of 4045 family members and 362 narcoleptic individuals were entered in… read more here.
Keywords: degree relatives; multiplex families; first second; narcolepsy symptoms ... See more keywords
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Psychiatry"
DOI: 10.1038/s41380-019-0558-2
Abstract: Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD)… read more here.
Keywords: risk; variants psychiatric; multiplex families; psychiatric disorders ... See more keywords
Phenotypic analysis of 303 multiplex families with common epilepsies
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DOI: 10.1093/brain/awx129
Abstract: Gene identification in epilepsy has mainly been limited to large families segregating genes of major effect and de novo mutations in epileptic encephalopathies. Many families that present with common non-acquired focal epilepsies and genetic generalized… read more here.
Keywords: epilepsy; common epilepsies; multiplex families; familial focal ... See more keywords
Exome sequencing in multiplex families with left-sided cardiac defects has high yield for disease gene discovery
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010236
Abstract: Congenital heart disease (CHD) is a common group of birth defects with a strong genetic contribution to their etiology, but historically the diagnostic yield from exome studies of isolated CHD has been low. Pleiotropy, variable… read more here.
Keywords: left sided; disease; sequencing multiplex; multiplex families ... See more keywords
Association of MAPK4 and SOX1-OT gene polymorphisms with cleft lip palate in multiplex families: A genetic study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Dental Research, Dental Clinics, Dental Prospects"
DOI: 10.34172/joddd.2020.021
Abstract: Background. Cleft lip and palate (CLP) is a common congenital anomaly. Many genes, like MAPK4 and SOX-1OT, are associated with its etiology in different populations. High-risk markers on these gene sreported in other populations were… read more here.
Keywords: sox 1ot; lip palate; multiplex families; study ... See more keywords