CRISPR interference-guided multiplex repression of endogenous competing pathway genes for redirecting metabolic flux in Escherichia coli
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DOI: 10.1186/s12934-017-0802-x
Abstract: BackgroundMultiplex control of metabolic pathway genes is essential for maximizing product titers and conversion yields of fuels, chemicals, and pharmaceuticals in metabolic engineering. To achieve this goal, artificial transcriptional regulators, such as clustered regularly interspaced… read more here.
Keywords: competing pathway; pathway genes; repression; coli ... See more keywords