Multiplexed functional genomic assays to decipher the noncoding genome.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac194
Abstract: Linkage disequilibrium and the incomplete regulatory annotation of the noncoding genome complicates the identification of functional noncoding genetic variants and their causal association with disease. Current computational methods for variant prioritization have limited predictive value,… read more here.
Keywords: noncoding genetic; genomic assays; multiplexed functional; assays decipher ... See more keywords
Abstract IA26: Multiplexed functional cancer genomics
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.camodels2020-ia26
Abstract: Extensive cancer genotyping has identified a large number of putative tumor-suppressor genes. However, genome sequencing data alone are insufficient to uncover the importance and role of these genes during carcinogenesis. Moreover, whether tumor suppressors restrict… read more here.
Keywords: functional cancer; multiplexed functional; tumor suppressor; cancer ... See more keywords